数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Cardiovascular diseases (CVDs) continue to be the leading cause of mortality worldwide.
方法
In an in vitro study using endothelial cell cultures from patients with atherosclerosis and restenosis, a significant increase in ET-1 expression was observed compared to that in normal endothelium; the addition of the KED peptide restored ET-1 expression to normal levels in these endothelial cell cultures.
核心结论
Medications play a key role in the prevention and management of age-related CVDs, among which an important place is occupied by peptides, a special class of molecules capable of modulating various physiological pathways involved in aging processes, including the restoration and regeneration of myocardial vessels.；This article presents a review of experimental studies investigating the mechanism of action of a vascular polypeptide preparation (VPP), as well as short peptides: the tripeptide KED, which is a component of VPP and possesses the same biological effects, and the tetrapeptide AEDR, whose biological activity is aimed at restoring myocardial function.；The results of experimental studies demonstrated that VPP exhibits specific angioprotective and angiogenic activity in vitro in cultures of human and mouse endothelial cells.；In… ‖ 结论：The results obtained from preclinical studies of VPP and short peptides suggest that peptide preparations represent a promising group for the prevention and treatment of age-related cardiovascular dysfunctions.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★☆☆☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。
原文题录
- 英文标题：[Peptidergic regulation of age-related alterations in the cardiovascular system.].
- 期刊与标识：Adv Gerontol · PMID 42935327 · DOI 10.34922/AE.2026.39.4.001**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。