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Compared with the BCG group, treatment with different doses of RES (L-RES, M-RES, H-RES) combined with BCG further upregulated the expression of LC3B-…

Histological and in vivo imaging studies have consistently demonstrated that retinal ganglion cells (RGCs) decline at an annual rate of approximately …

结论：Overall, SCeNS provides an effective tool that allows for the comparison and communication of diverse biological data.

It is an important risk factor for cardiovascular diseases (CVD) and accounts for 20% of deaths worldwide [3].；Most patients develop primary hypertens…

Cellular senescence is itself heterogeneous: p16 and p21 expression, SA-β-gal activity, and SASP components vary across cell types, tissues, and senes…

在慢性鼻窦炎伴嗅觉障碍的小鼠模型中，SIRT3 缺失加剧嗅感觉神经元丢失；机制是巨噬细胞 HIF-1α 上调、糖酵解增强、线粒体膜电位下降。

The mice dedicated to immunohistochemical analysis were perfused intra- cardially with saline followed by 10% buffered forma- lin and immersion fixed …

We analysed clinical data from 69 patients aged 65–83 years (median age 74 years), representing 2.9% (69/2378) of all new STIs diagnoses recorded betw…

For peripheral line crossings, the Two-Way Repeated Measures ANOVA demonstrated a significant Time × Group interaction [F(4, 30) = 3.093, p = 0.0303],…

After Benjamini–Hochberg correction across the six two-sided tests, all six had BH-adjusted q values below 0.10, although only one met the prespecifie…

Early-phase SASP is characterized by secretion of transforming growth factor-β (TGF-β), chemokines, and pro-inflammatory cytokines.；When TGF-β signali…

The participants were predominantly male 72.1%. ‖ 结论：These findings support the potential of serum NfL as a non-invasive biomarker for early detection…

Among boys, higher NA concentrations at baseline were associated with lower internalizing (β = −3.733, 95% CI: −6.686 to −0.779), externalizing (β = −…

Coefficients were exponentiated and reported as percentage differences with 95% CIs.；Their 95% percentile CIs were obtained by case bootstrapping with…

We observed an increase in body weight in female 3xTg-AD mice at 6 months (24.1%) and 12 months (28.3%) compared to B6129 mice.；This corresponded with…

We found no significant main effect of sex on memory retention, F(1,58) = .13, p = .72, partial η2 = .002.；The overall model was not significant, F(4,…

Forty-nine male SD rats were randomly divided into control group, sham-operated group, unilateral ureteral obstruction (UUO)-induced RF model group, l…

At the signaling level, peri- cyte contractility is regulated by multiple mediators, including platelet-derived growth factor-β (PDGF-β) and adenosine…

Therefore, the aim of this study was to investigate the effect of a hyaluronic acid-based hydrogel with a chelated form of zinc and silicon on the exp…

A total of 47,537 high-quality cells were analyzed using the Seurat pipeline.；Differential expression, pathway enrichment (gene set enrichment analysi…

We delineated a nonlinear, diabetes-specific pathological trajectory characterized by early inflammatory activation, a mid-stage inflection in neurode…

Transfected cells were treated with cambinol (100 µM), vehicle control (VC), and VC containing 1% DMSO to match the DMSO concentration present in 100 …

To formally assess bioequivalence, 90% confidence intervals (CIs) were calculated for the geometric mean ratios (Test/Reference) of the log-transforme…

The majority of participants were married (92.33%), resided in rural areas (64.27%), did not consume alcohol (64.31%), and were nonsmokers (68.35%).；E…

The sample included 16 males (21.3%) and 59 females (78.7%), with mean age 72.32 years (SD = 6.03).；Age did not differ by sex (p = 0.614), nor did oth…

The 2024 Lancet Commission estimated that addressing 14 modifiable factors, including depression and social isolation, could prevent or delay up to 45…

The study duration averaged 70 months (SD 5.38) with a sample mean age of 62 years (9.83) and 60.64% women.；There was evidence of effect modification …

SOY reduced final BW in the βKO mice by ~17%, which was not evident in the WT (0%) or αKO (6%) mice.；This associated with a trend toward lowered fat m…

In the aMCI group, NTA had the highest selection frequency (69.1%), followed by PA (52.0%) and PE (50.6%).；In older adults, PE was most frequently sel…