数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
（原文未设独立引言节）
方法
Imaging-validated correlates and impli- cations of the pathophysiologic mechanisms of ageing- related cerebral large artery and small vessel diseases: a systematic review and meta-analysis.
核心结论
At the signaling level, peri- cyte contractility is regulated by multiple mediators, including platelet-derived growth factor-β (PDGF-β) and adenosine [68].；Moreover, BBB integrity is regulated by several signaling pathways, including the Wnt/β-catenin, TGF-β, PDGF-β, and Shh signaling pathways [81].；Similarly, coordinated regulation of both pathways by oxidative stress, NF-κB, TGF-β, cellular senescence, and the senescence-associated secretory phenotype remains mechanistically plausi- ble but has not been directly established in the age- ing NVU.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★☆ 线粒体端点既是机制解释层，也是最容易拿到体外 / 影像读数的中间层。命中核心 线粒体；设计 Meta 分析、系统综述。
全文来源
Springer OA PDF（正文 102,979 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Sonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link.
- 期刊与标识：Geroscience · PMID 42945031 · DOI 10.1007/s11357-026-02619-8**
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