数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
The aim of this review is to summarize current evidence regarding the interplay between T2DM and OA, with particular emphasis on their epidemiological associations, shared risk factors and underlying molecular mechanisms.
方法
In vitro, chondrocytes were exposed to high glucose levels to mimic diabetic conditions [117].；They identified a total of 16 genes associated with OA progression, and the genes encoding catabolic factors, such as MMPs (MMP-3 and MMP-13) and nitric oxide synthase-2 (NOS2), were found to be upregulated in DM-OA chondrocytes.
核心结论
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is a chronic metabolic disorder characterized by insulin resistance, progressive β-cell dysfunction and persistent hyperglycemia affecting more than 10% of the adult population worldwide.；Consistent with this, a large cohort study involving 1,764,061 subjects revealed that obese individuals with grade 2 obesity were 4.7-fold more frequently diagnosed with knee OA (KOA) compared to healthy subjects independent of background pathology [31].；5.70 ± 0.07, p < 0.0001; METS-VF: 7.26 ± 0.04 vs. ‖ 结论：A better understanding of the interactions between metabolic dysfunction and joint disease may facilitate the development of personalized therapeutic strategies and integrated care models aimed at reducing the growing health and socioeconomic burden associated with both T2DM and OA.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★☆ 线粒体端点既是机制解释层，也是最容易拿到体外 / 影像读数的中间层。命中核心 mTOR/AMPK；队列：NHANES、KNHANES；最大样本量约 764,061；设计 RCT、孟德尔随机化。
全文来源
PMC JATS 全文（正文 63,291 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Exploring Pathophysiological Processes Shared Between Type 2 Diabetes Mellitus and Osteoarthritis.
- 期刊与标识：Int J Mol Sci · PMID 42941937 · DOI 10.3390/ijms27209168**
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