数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Childhood behavioral and emotional problems are a major public health concern.
方法
Matching nonmissing participant identifiers between the main and CBCL worksheets yielded 222 linked children (119 boys and 103 girls); 206 had all three broadband CBCL outcomes recorded in 2025.；Written informed consent was obtained from all participants and/or their legal guardians.；Child Behavior Measurement] The Child Behavior Checklist (CBCL), part of the Achenbach System of Empirically Based Assessment, is widely used to assess caregiver-reported behavioral and emotional problems in children [5,6].
核心结论
Among boys, higher NA concentrations at baseline were associated with lower internalizing (β = −3.733, 95% CI: −6.686 to −0.779), externalizing (β = −5.204, 95% CI: −8.517 to −1.891), and total-problem scores (β = −9.198, 95% CI: −14.632 to −3.763).；Among girls, higher nicotinic acid concentrations at follow-up were nominally associated with higher externalizing (β = 2.240, 95% CI: 0.180 to 4.300) and total-problem scores (β = 4.248, 95% CI: 0.601–7.894); however, neither association remained significant after Benjamini–Hochberg false-discovery-rate correction (FDR-adjusted p = 0.24 and 0.12, respectively). ‖ 结论：In conclusion, this exploratory study found no corrected evidence of pooled associations between serum NA or NAM and broadband CBCL raw scores in children.
局限
Interaction analyses suggested sex heterogeneity for 2021 NA across the three broadband outcomes and several low-count subscales.；The 2021 NA pattern in boys is sufficiently coherent to motivate replication, but it does not establish a protective effect.；Accordingly, null spline tests cannot exclude effects below the reported detection thresholds, and the corrected sex-stratified signals should not be interpreted as establishing reproducible sex-specific dose–response relations.
对本项目的价值
★★★☆☆ NAD⁺ 轴是最接近临床可转化的代谢干预节点，直接影响 NAD 前体 / CD38 抑制策略取舍。命中核心 NAD⁺轴；最大样本量约 201；设计 Meta 分析、前瞻队列。
全文来源
PMC JATS 全文（正文 17,336 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Associations of Serum Niacin and Nicotinamide with Child Behavior: A Longitudinal Study in China.
- 期刊与标识：Nutrients · PMID 42942915 · DOI 10.3390/nu18203344**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。