数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Serum thyroid-stimulating hormone (TSH) is central to the evaluation of primary thyroid dysfunction, yet its interpretation in later life is not straightforward.
方法
Participants] The clinical screening log documented 477 outpatient encounters.；Twenty-one repeat encounters were removed, leaving 456 unique patients for eligibility assessment.；Patients were excluded for documented hypothyroidism, hyperthyroidism, or thyroid cancer; levothyroxine use; previous thyroid surgery or radioactive iodine treatment; medications known to affect thyroid function (including amiodarone, glucocorticoids, lithium, levodopa, phenobarbital, phenytoin, carbamazepine, propranolol, propylthiouracil, tyrosine-kinase inhibitors, interferon, interleukin-2, octreotide, dopamine, or dobutamine); active malignancy; or acute infection or inflammatory disease.；Acute illness, including infection and acute flares of malignant or rheumatological disease, was ruled out based on history, physical examination, and laboratory tests; patients with an erythrocyte sedimentation rate ≥ 30 mm/h, C-reactive protein ≥ 5 mg/L, and/or a leukocyte count ≥ 11,000/µL were excluded.
核心结论
Coefficients were exponentiated and reported as percentage differences with 95% CIs.；Their 95% percentile CIs were obtained by case bootstrapping with 5000 resamples (seed 20260829). ‖ 结论：The findings support confirmation of isolated TSH abnormalities and consideration of within-person change and clinical context in older outpatients; whether sex-specific interpretation improves clinical classification cannot be determined from this cohort.
局限
First, the single-center, retrospective, cross-sectional design cannot separate aging from cohort, survivor, or referral effects, and only 17 participants were aged ≥85 years.；Fourth, 250 of the 456 screened patients were excluded, most often for elevated inflammatory markers or insufficient laboratory data, which may have introduced selection bias; individual-level characteristics of the excluded patients were not retained, so they could not be compared with those of the included cohort.
对本项目的价值
★★☆☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。队列：NHANES；最大样本量约 206；设计 系统综述、横断面。
全文来源
PMC JATS 全文（正文 31,407 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Serum Thyrotropin Levels Across Older Age Groups in Geriatric Outpatients Without Documented or Clinically Evident Thyroid Disease: A Retrospective Cross-Sectional Study.
- 期刊与标识：J Clin Med · PMID 42941572 · DOI 10.3390/jcm15208059**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。