数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
The progressive increase in life expectancy has intensified interest in identifying the mechanisms that support autonomy, social participation, and health-related quality of life (HRQoL) during aging [1,2,3].
方法
Twenty-three participants (12 Older Adults; 11 MCI patients) (Mage_OA = 71, SDage_OA = 1.65, Mage_MCI = 73, SDage_MCI = 4.75, Meducation_OA = 13.66, SDeducation_OA = 2.01, Meducation_MCI = 12, SDeducation_MCI = 5) were recruited.；Informed consent was obtained from all participants.；The aMCI patients’ mean MMSE score was 25.18, SD = 3.43 (corrected = 26.53, SD = 3.78), and the MoCA score was 20.09, SD = 4.41 (corrected = 25.62, SD = 2.88).；Older participants were recruited at the Laboratory of Cognitive Science and Immersive Virtual Reality, in conformity with the requirements of the local Institutional Ethics Committee [N.
核心结论
In the aMCI group, NTA had the highest selection frequency (69.1%), followed by PA (52.0%) and PE (50.6%).；In older adults, PE was most frequently selected (72.4%), followed by NTE (63.0%).；The remaining spatial predictors were selected in fewer than 50% of bootstrap samples in both groups. ‖ 结论：Overall, the present findings suggest that spatial processing and self-reported body awareness are associated with different domains of health-related quality of life, with partially distinct patterns observed in OA and individuals with aMCI.
局限
Fourth, the cross-sectional design provides information on associations but does not allow temporal or causal relationships to be established.
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 11；设计 横断面、问卷。
全文来源
PMC JATS 全文（正文 43,389 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：When Body and Space Shape Perceived Health: Spatial and Interoceptive Processes in Amnestic Mild Cognitive Impairment.
- 期刊与标识：J Clin Med · PMID 42941303 · DOI 10.3390/jcm15207787**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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