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共 2198 篇，本页第 1321–1350 篇
The young stem cell-transplanted mice exhibited a 16% increase in lifespan.；The results showed that the BMSC-transplanted mice had an average extensio…
结论：We further demonstrated that this pathway mediated restraint stress–induced inhibition of NLRP6 inflammasome and autophagy, leading to impaired gob…
Matching achieved close balance on all variables entered into the assignment: the standardised mean difference was 0.15 for age, −0.02 for height, and…
1.08 μmol/g, respectively), which translates to a 15-fold increase in glucoraphanin content between these two forms of broccoli [29].；In a human kinet…
This study aimed to examine age- and sex-related differences in NWES-derived swallowing-related time metrics and their relationship with masticatory f…
This issue is particularly acute because many fundamental studies still rely on T cells from, mostly, healthy young donors. ‖ 结论：As the immune system …
In this review, we examine how TDP-43 dysfunction disrupts lineage-specific glial homeostatic programs and promotes distinct pathological state transi…
Comparisons with benchmark assays were performed.；Good detectability (CSF: 31 out of 42 assays; plasma: 38 out of 42 assays) and technical performance…
Telomerase activity is usually low or undetectable in most normal somatic cells, whereas it is detected in most human cancers (up to 90%), where it su…
A recent study using an animal model showed that at nonphysiological oxygen levels (~20% O2), mouse embryos exhibited reduced telomere elongation duri…
Genotyping of the hTERT-MNS16A variant was performed through polymerase chain reaction (PCR), while relative LTL was measured using real-time PCR.；For…
There was a non-significant tendency towards lower levels in men (179.1 ± 73.8 ng/mL) compared to women (193.1 ± 78.9 ng/mL, p = 0.060 by Mann–Whitney…
It has been demonstrated that chronological age does not adequately reflect individual differences in aging rates and functional status.；Therefore, pa…
In young rats, a statistically significant difference was observed among groups in terms of malondialdehyde (MDA) and sirtuin 2 (SIRT2) levels (p < 0.…
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is a chronic metabolic disorder characterized by insulin resistance, progressive β-…
结论：This study was designed to compare the predicted AD-related mechanisms of UDCA and TUDCA from the perspectives of target overlap, pathway preferenc…
用 BMI、HbA1c、总胆固醇、ALT、eGFR、收缩压、白细胞计数七项指标做非参数排序，NHANES 1988–2018 显示健康分布显著恶化且集中在下尾；反事实分解显示约三分之一可归因于人口老龄化与族裔结构变化。
Data are presented as means ± SEM with individual values shown. *P<0.001, P<0.0001.；Data are presented as means ± SEM. P<0.0001. ‖ 结论**：The present st…
A significant Treatment × Day interaction was observed in db/+ mice (p = 0.046), whereas no significant interaction was detected in db/db mice.；A sign…
ClinicalTrials.gov 记录于 2026-10-28 更新（仍为招募中）：验证 Vibegron 能否改善中老年肥胖者的能量代谢、心血管代谢风险因素与体能、认知功能。
A ViT model was fine-tuned on [Formula: see text] ROI-to-ROI connectivity matrices to perform three binary age group classifications (Young versus Old…
一篇 Perspectives 梳理 ACSL4 驱动的铁依赖性衰老轨迹（ferro-aging），并审视维生素 C 抑制 ACSL4 的非人灵长类证据——同时明确指出分子机制未确认、人体有效性未验证。
Gut Microbiome Analysis] After a rigorous quality check and preprocessing, which removed about 20% of the sequences, all sequences were normalized to …
A total of 141 participants were included in the final analysis, with a mean age of 74.8 ± 6.6 years; 77 (54.6%) were women.；According to the GLIM cri…
Nested model comparisons showed that incorporating these patterns significantly improved model fit across all 144 WM metrics—the mean ΔR2 was 0.1897 (…
In our study, the highest MDA and lowest GSH levels in hippocampal tissue were obtained in CPZ group (Group 3) and CPZ group fed a zinc-deficient diet…
There were no significant differences in sex distribution between the groups (p = 0.240).；44.34 years, p < 0.001), while the T1DM group was characteri…
Seven-month-old male APP/PS1 mice were randomly divided into AD-vehicle and AD-hucMSC-exosome groups, with age-matched C57BL/6 mice as wild-type contr…
However, the role of the lncRNA RMRP in endothelial cell injury and its potential molecular mechanisms remain unclear.；Mouse aortic endothelial cells …