数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
This review examines current perspectives on the theory of resilience as a promising concept in geriatrics and longevity medicine.
方法
Modern data on the biological mechanisms of aging, risk factors for age-associated diseases, the concept of biological age, epigenetic clocks, and proxy diseases of aging were analyzed.
核心结论
It has been demonstrated that chronological age does not adequately reflect individual differences in aging rates and functional status.；Therefore, particular importance is attributed to integrated indicators capable of assessing adaptive reserves and the organism's resistance to age-related changes.；The review discusses the potential application of epigenetic clocks as molecular biomarkers of biological aging, as well as the role of sarcopenia, frailty, cognitive impairment, and metabolic disorders as proxy diseases of aging.；These conditions are shown to reflect the systemic nature of age-related changes and to be associated with decreased functional independence and increased mortality risk. ‖ 结论：These conditions are shown to reflect the systemic nature of age-related changes and to be associated with decreased functional independence and increased mortality risk.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★★☆☆ 生物学年龄读数是选择替代终点的主要候选，直接影响终点设计与样本量估算。
原文题录
- 英文标题：[Theory of resilience in geriatric medicine.].
- 期刊与标识：Adv Gerontol · PMID 42935332 · DOI 10.34922/AE.2026.39.4.006**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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