数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Diabetes is a chronic metabolic disease characterized by hyperglycemia as well as disturbed metabolism of carbohydrates, lipids, and proteins, which generates an enormous health and economic burden worldwide [1,2].
方法
The study cohort consisted of 117 T1DM and 144 T2DM patients (131 women and 130 men), aged between 18 and 87 years, who volunteered to participate in the study during their in-patient stay at the Department of Diabetes at the Institute of Rural Health in Lublin, Poland.；Patients were recruited as a consecutive, real-world clinical cohort.；Patients were excluded only if they met any of the following criteria: (1) pregnancy; (2) lack of conscious written informed consent; or (3) missing essential clinical, biochemical, or genotypic data necessary for the final analysis.；Data Collection and Biochemical Ana] To obtain a comprehensive assessment of the patients’ clinical status, demographic and medical data were extracted from hospital records.
核心结论
There were no significant differences in sex distribution between the groups (p = 0.240).；44.34 years, p < 0.001), while the T1DM group was characterized by a significantly longer duration of the disease (20.00 vs.；25.70 kg/m2, p < 0.001) and waist circumference (WC) (114.87 vs. ‖ 结论：In conclusion, our findings demonstrate that while hTERT promoter polymorphisms are not directly associated with leukocyte telomere length under the heavy metabolic pressure of diabetes, they may exhibit clinically relevant phenotypic associations independent of systemic leukocyte RTL.
局限
Nevertheless, we uncovered several intriguing, genotype-specific associations with baseline metabolic phenotypes that appear to function independently of systemic leukocyte RTL, and therefore warrant discussion.；Such conflicting findings often arise due to incomplete study designs or low statistical significance caused by small sample sizes [49].；The cross-sectional design of our study prevents us from establishing direct causal relationships over time.
对本项目的价值
★★★☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。命中核心 线粒体；最大样本量约 144；设计 横断面。
全文来源
PMC JATS 全文（正文 42,306 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Telomere-Independent Associations of hTERT Promoter Polymorphisms with Metabolic Phenotypes and Diabetic Complications.
- 期刊与标识：Int J Mol Sci · PMID 42942062 · DOI 10.3390/ijms27209292**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。