数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
However, the transcriptome-wide molecular programs associated with failure of the aged uterus to mount a coordinated decidual response remain incompletely defined, and these molecular changes have not been integrated with PGR localization, stromal cell function, and ECM remodeling within the same experimental model.
方法
C57BL/6 J virgin female mice used in this study were either young virgin female mice, 6–8 weeks of age, or aged virgin female mice, 46–54 weeks of age.；Young and aged female mice were bilaterally ovariectomized and allowed to recover for 2 weeks to eliminate influences of endogenous ovarian steroids.；Mice were primed with 17β-estradiol (E2; E8875, Sigma-Aldrich, St.
核心结论
Data are presented as means ± SEM with individual values shown. *P<0.001, P<0.0001.；Data are presented as means ± SEM. P<0.0001. ‖ 结论**：The present study extends these observations by integrating PGR localization, transcriptome-wide profiling, primary stromal cell responses, and quantitative ECM analyses within the same controlled artificial decidualization model.
局限
Cell-resolved and spatial approaches will be required to distinguish these possibilities in future studies.；Transcriptomic analyses were limited to DD2 because increasing cellular heterogeneity at later stages complicates interpretation of bulk tissue datasets.
对本项目的价值
★★☆☆☆ 生殖衰老提供"衰老速率可被激素轴调节"的天然实验窗口。最大样本量约 12；设计 多组学。
全文来源
PMC JATS 全文（正文 51,240 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Uterine function and reproduction aging. I. Molecular and structural alterations associated with impaired decidualization in aged mouse uteri.
- 期刊与标识：Uterine Res · PMID 42935627 · DOI 10.1186/s44494-026-00007-9**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
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