数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Population ageing has increased the number of adults living with progressive losses of skeletal muscle strength, muscle quantity and quality, and cardiorespiratory fitness.
方法
Comparators included placebo, no supplementation, usual care, or an otherwise equivalent background intervention.；Biochemical markers, subjective fatigue, quality of life, pain, and other patient-reported outcomes alone were insufficient for eligibility.；Randomized parallel-group, crossover, and factorial designs were eligible when random allocation was verifiable; crossover trials additionally required randomized treatment sequence.；Non-randomized and quasi-randomized studies, single-arm or observational studies, acute non-supplementation experiments, protocols, reviews, case reports, and animal or in vitro studies were excluded.
核心结论
The union of the five original exports retrieved all 33 final included reports (100%), although no single database was complete.；Overall, two trials (6.1%) were judged to be at low risk of bias, 16 (48.5%) raised some concerns, and 15 (45.5%) were judged to be at high risk of bias.；For the randomization process, nine trials (27.3%) were low risk and 24 (72.7%) raised some concerns, mainly because sequence generation or allocation concealment was underreported. ‖ 结论：Randomized crossover trials should use a washout of at least 4 weeks when biologically appropriate, justify any alternative interval for the selected dose and formulation, and report paired analyses and within-participant correlations.
局限
Although pooling was restricted to outcomes judged to represent sufficiently comparable clinical constructs, residual clinical heterogeneity remains because the same performance measure may reflect different physiological limitations across healthy, cardiovascular, metabolic, renal, and neuromuscular populations.；Random-effects modelling addresses statistical heterogeneity but cannot eliminate these differences in clinical context.；These differences did not warrant a GRADE downgrade for indirectness because they occurred within the prespecified broad target population and the pooled outcomes represented comparable constructs; nevertheless, they restrict the extent to which the average…
对本项目的价值
★★★★★ 干预证据决定参照标准效应量——任何抗衰干预的收益至少应对标该基线。命中核心 线粒体；最大样本量约 3,317；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 61,115 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Effects of Coenzyme Q10 Supplementation on Muscle Health and Physical Capacity in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- 期刊与标识：Antioxidants (Basel) · PMID 42939793 · DOI 10.3390/antiox15101219**
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