数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Insulin-like signaling modulates aging and lifespan in insects.
方法
Here, we discuss a novel view of this control: insulin hormone in the adult regulates the production of the sesquiterpenoid juvenile hormone (JH) that in turn acts as the systemic regulator of aging and lifespan.
核心结论
Work in Drosophila establishes that insulin signaling is allatotropic - it stimulates the production and secretion of JH from the corpora allata.；JH then exerts systemic effects on adult survival through its control of specific proteins, translation and proteostasis.；The interdependent functions of insulin and JH allow reproduction and longevity to be coupled in many insects or decoupled in social insects with long-lived queens and in some long-lived genetic mutants of Drosophila.；Features of these insulin-regulated life history syndromes are also found in the nematode Caenorhabditis elegans. ‖ 结论：Features of these insulin-regulated life history syndromes are also found in the nematode Caenorhabditis elegans.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★★☆☆ 生殖衰老提供"衰老速率可被激素轴调节"的天然实验窗口。
原文题录
- 英文标题：Toward a comparative endocrinology of aging: insights from insects.
- 期刊与标识：J Exp Biol · PMID 42948917 · DOI 10.1242/jeb.253055**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。