数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
A secondary, exploratory aim was to examine whether the two exposures interact within each domain.
方法
Stroke participants were recruited under the same institutional ethics approval and laboratory programme as earlier work from our group on post-stroke gait [15,16].；Several participants had been assessed on more than one occasion within the same source cohort; for these individuals a single record was retained, defined as the observation with the greatest age at assessment.；The signed age term was included because the available pool was younger than the stroke cases, so that distance minimisation alone would have produced a control group younger than the cases; it was weighted so that the total age of the selected controls was maximised first and the total Mahalanobis distance minimised second.
核心结论
Matching achieved close balance on all variables entered into the assignment: the standardised mean difference was 0.15 for age, −0.02 for height, and 0.02 for weight, and sex was matched exactly (33.3% women in both groups).；The phenotype was associated with strength (V = 0.335, F(14, 168) = 2.42, p = 0.004, Holm p = 0.008, 0.17), gait performance (V = 0.244, F(6, 182) = 4.21, p < 0.001, Holm p = 0.003, 0.12), and gait variability (V = 0.197, F(6, 182) = 3.31, p = 0.006, Holm p = 0.008, 0.10). ‖ 结论：These are conditional cross-sectional associations in a selected cohort.
局限
The design was cross-sectional, and the results are conditional associations in a selected cohort; they do not show that stroke and a sarcopenia-related process exert independent biological effects.；No formal index-stroke severity measure was available, and clinical characterisation was missing for three stroke participants.；The controls were drawn from five institutional cohorts rather than a single sampling frame; adding source-cohort indicators changed no judgement, but differences in measurement setting cannot be fully excluded.
对本项目的价值
★★☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。最大样本量约 99；设计 系统综述、横断面。
全文来源
PMC JATS 全文（正文 38,286 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Independent Associations of Stroke and Sarcopenia-Related Phenotype with Lower-Limb Strength and Gait: A 1:2 Matched Cohort Analysis.
- 期刊与标识：J Clin Med · PMID 42941295 · DOI 10.3390/jcm15207779**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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