数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Despite these advances, the assessment of malnutrition in older adults continues to rely primarily on anthropometric measurements and clinical indicators (6), while the metabolic alterations associated with malnutrition remain incompletely characterized.
方法
Only baseline measurements obtained during hospitalization were included in the analysis; no longitudinal follow-up data were evaluated.；Eligible participants met the following inclusion criteria: (1) age ≥60 years; (2) hospital stay ≥7 days; and (3) ability to undergo body composition assessment and indirect calorimetry.；Written informed consent was obtained from all participants before enrollment.；Medical history included both chronic and acute medical conditions.
核心结论
A total of 141 participants were included in the final analysis, with a mean age of 74.8 ± 6.6 years; 77 (54.6%) were women.；According to the GLIM criteria, 74 participants (52.5%) were classified as malnourished and 67 (47.5%) as non-malnourished.；Compared with participants without malnutrition, those with malnutrition had significantly lower BMI, ADL and IADL scores, handgrip strength, FFM, and SMI (all p < 0.05). ‖ 结论：This study showed that RMR normalized by body weight was independently associated with GLIM-defined malnutrition and sarcopenia in hospitalized older adults undergoing CGA.
局限
Given the cross-sectional design, the temporal sequence and causal direction of these relationships cannot be determined.；First, the cross-sectional design precludes determination of temporal or causal relationships among RMR/weight, malnutrition, and sarcopenia.
对本项目的价值
★★☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。最大样本量约 141；设计 横断面。
全文来源
PMC JATS 全文（正文 25,997 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Body weight-normalized resting metabolic rate and its associations with malnutrition and sarcopenia in hospitalized older adults: a cross-sectional study.
- 期刊与标识：Front Nutr · PMID 42936014 · DOI 10.3389/fnut.2026.1914763**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。