数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Tenascins are a family of extracellular matrix (ECM) glycoproteins involved in developmental processes and connective tissue structure.
方法
Influence of Glucocorticoid Administration on TNX Levels To determine any influence of acute dexamethasone administration on TNX levels, we measured TNX after DST in a subgroup of individuals (n = 37).；TNC Levels and Clinical Correlates TNC levels were determined in a subgroup of individuals included in this study (n = 154; male n = 47; female n = 107).；We measured TNX and TNC serum levels by immunoassay, a method generally susceptible to matrix interference; furthermore, the preferential detection of specific TNX isoforms by the assay cannot be excluded.；Methods and Materials This study is a retrospective cohort analysis that was approved by the institutional review board of the Medical University of Vienna (EK 1336/2021) and was conducted in accordance with the Declaration of Helsinki.
核心结论
There was a non-significant tendency towards lower levels in men (179.1 ± 73.8 ng/mL) compared to women (193.1 ± 78.9 ng/mL, p = 0.060 by Mann–Whitney U test).；Specifically, for every 1-year increase in age, TNX levels decreased by approximately 0.4%, holding all other variables constant.；For every 1 cm increase in height, TNX levels increased by approximately 0.9%, holding all other variables constant. ‖ 结论：We show here the clinical correlates of serum TNX and TNC levels in a heterogenous cohort of individuals with prevalent cardiometabolic risk factors.
局限
Furthermore, the absence of a significant effect should be interpreted with caution given the small size of this subgroup.；There is considerable heterogeneity in the previous literature connecting TNC levels and age as well as cardiometabolic risk parameters [31,32,33].；Second, our data indicate that TNX measurements are not acutely altered by a single dose of dexamethasone, whereas the effect of chronic glucocorticoid treatment remains to be determined.
对本项目的价值
★★☆☆☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。最大样本量约 274；设计 回顾性。
全文来源
PMC JATS 全文（正文 22,447 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Tenascin X and Tenascin C Serum Levels in Relation to Age and Cardiometabolic Risk Parameters.
- 期刊与标识：Int J Mol Sci · PMID 42941950 · DOI 10.3390/ijms27209180**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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