数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Recent global estimates reported close to 20 million new cancer cases and 9.7 million cancer-related deaths worldwide [1].
方法
In this review, resistance, stress adaptation, sensitization, potentiation, and synergy are treated as distinct biological and experimental outcomes, rather than interchangeable terms (Box 1).
核心结论
Telomerase activity is usually low or undetectable in most normal somatic cells, whereas it is detected in most human cancers (up to 90%), where it supports telomere maintenance during sustained proliferation [6,7,23].；For example, overexpression of the β-deletion variant inhibited endogenous telomerase activity while reducing cisplatin-induced apoptosis in breast cancer cells [34].；MST-312 followed a similar pattern at non-toxic concentrations, producing gradual telomere shortening, slower proliferation, and senescence-associated β-galactosidase (SA-β-Gal) activity [72]. ‖ 结论：In this context, telomerase targeting may be more useful as a selected sensitization strategy than as a universal anticancer monotherapy.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★☆☆☆ 相关范围内，作为背景与横向对照收录。
全文来源
PMC JATS 全文（正文 57,110 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The Role of Telomerase in Cellular Stress Response-Therapeutic Potential of Telomerase Inhibitors.
- 期刊与标识：Biomedicines · PMID 42939977 · DOI 10.3390/biomedicines14102171**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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