数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Hypertension is one of the most prevalent diseases worldwide, affecting almost 1.5 billion people [1].
方法
Then, we extended date range and added the terms “patients” or “human”, or combined the word “SIRT1” with “preeclampsia” in order to find more articles on human subjects, which yielded 318 more results.；Only full-text original articles were included.；These included studies in language other than English, referred to SIRT1 role in diseases other than hypertension, or did not provide information about SIRT1 effects in hypertension.
核心结论
It is an important risk factor for cardiovascular diseases (CVD) and accounts for 20% of deaths worldwide [3].；Most patients develop primary hypertension, while only approximately 10% are diagnosed with secondary hypertension [2].；Pharmacological therapy with proven clinical outcome benefits in the target population includes angiotensin converting enzyme (ACE) inhibitors/angiotensin II (Ang II) receptor blockers, dihydropyridine calcium channel blockers, diuretics (thiazide and thiazide-like), and β-blockers [2]. ‖ 结论：These observations require confirmation in adequately powered, well-designed clinical trials evaluating long-term CV outcomes.
局限
A major limitation is the inconsistent use of SIRT1 inhibition strategies across the included studies.；The lack of precise data on BP values is another important limitation of the available studies.；This heterogeneity in outcomes limits direct comparisons across studies and complicates the interpretation of the overall effect of SIRT1 activation on BP.
对本项目的价值
★★★★☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。命中核心 NAD⁺轴；队列：UK Biobank、FHS；设计 系统综述、前瞻队列。
全文来源
PMC JATS 全文（正文 86,819 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Sirtuin-1 in Hypertension: Linking Oxidative Stress and Mitochondrial Dysfunction to Vascular Aging and Therapeutic Potential.
- 期刊与标识：Antioxidants (Basel) · PMID 42939927 · DOI 10.3390/antiox15101353**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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