数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Whether some of the systemic organ dysfunctions in AD are a direct result of the neurodegenerative processes or related to AD-induced changes in life- style due to cognitive limitations is not fully under- stood.
方法
Animals Male and female 3xTg-AD mice (B6;129- Tg(APPSwe,tauP301L)1Lfa Psen1tm1Mpm /Mmjax) (RRID:MMRRC:034830-JAX) were obtained from the Mutant Mouse Resource & Research Centers (MMRRC) and bred for use in all experiments by Dr.；Control B6129 mice (RRID:IMSR_ JAX:101045) were purchased from The Jackson Laboratory and used for age and sex-matched groups as needed, and aging occurred at Indiana Univer- sity School of Medicine.；B6129 mice can exhibit some phenotypic variability, and we acknowledge this as a concern.；This approach reduces the most significant confounding variable—genetic back- ground heterogeneity between experimental and con- trol groups since the 3xTg-AD mice were originally developed on this genetic background [25].
核心结论
We observed an increase in body weight in female 3xTg-AD mice at 6 months (24.1%) and 12 months (28.3%) compared to B6129 mice.；This corresponded with an increase in lean mass at 6 months (11.3%) and an increase in fat mass at 6 months (92.9%) and 12 months (145.0%) com- pared to control B6129 mice (Fig.；In male 3xTg-AD mice compared to control B6129 mice, we observed that whole body weight was lower at 3 months (−12.8%) and 6 months (−16.0%) and there was no difference in body weight at 12 months. ‖ 结论：Our study provides further evidence that AD, tradi- tionally understood as a central nervous system dis- order, also exerts profound and progressive effects on skeletal muscle mass and function.
局限
To better assess this role, future studies are needed to assess mitochondrial content, respiratory capacity, oxidative stress, and lipid handling in skeletal muscle of 3xTg-AD mice.；By identifying skeletal muscle as a modifiable target, new strategies for improving quality of life and functional independence in individuals living with AD should be considered.
对本项目的价值
★★★★☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。最大样本量约 9；设计 Meta 分析、系统综述。
全文来源
Springer OA PDF（正文 45,548 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Characterization of sex-dependent skeletal muscle alterations in the 3xTg Alzheimer's disease mouse model.
- 期刊与标识：Geroscience · PMID 42946892 · DOI 10.1007/s11357-026-02569-1**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。