数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Chronic genotoxic stress leads to the development of inflammaging in human skin fibroblasts, a condition characterized by the accumulation of DNA damage, overexpression of pro-inflammatory factors, and degradation of the extracellular matrix, which makes it important to find ways to correct these processes.
方法
In the experimental samples, a preparation based on hyaluronic acid with a chelated form of zinc and silicon was added to the culture, after which the expression of these biomarkers was evaluated.；In all the samples studied, the addition of the preparation to a culture of fibroblasts exposed to genotoxic stress resulted in a significant restoration of the proliferative (associated with Ki-67) and biosynthetic functions of dermal fibroblasts, as well as a decrease in key markers of inflammaging.
核心结论
Therefore, the aim of this study was to investigate the effect of a hyaluronic acid-based hydrogel with a chelated form of zinc and silicon on the expression of cellular aging biomarkers CCN1, IL-8, Ki-67, MMP-3, NF-κB/p65, and TIMP1 in human skin fibroblast cultures under genotoxic stress.；Inflammaging modeling was performed on human dermal fibroblasts by exposure, causing a critical threshold of damage to chromosomal DNA.；The results showed that genotoxic stress in this model activates the degradation of extracellular matrix proteins and causes a sharp increase in the expression of IL-8, CCN1, and NF-κB. ‖ 结论：Thus, a hyaluronic acid-based preparation with a chelated form of zinc and silicon effectively corrects the molecular signs of cellular aging and the inflammatory phenotype under genotoxic stress, which justifies its potential use for the prevention and correction of age-related skin changes.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★☆☆☆ 皮肤是唯一可直接局部给药、可活检、可影像量化的器官，最快可验证 senotherapeutic 概念。
原文题录
- 英文标题：[Signaling molecules and skin aging: Targeted prevention approaches in molecular cosmetology.].
- 期刊与标识：Adv Gerontol · PMID 42935340 · DOI 10.34922/AE.2026.39.4.014**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。