数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Research has shown that the brain changes associated with the disease occur years before the symptom onset in Alzheimer's disease.
方法
In addition, proteomic measurements from the liquid chromatography–mass spectrometry (LC‐MS) based C2N PrecivityAD2 platform in Alzheimer's Disease Neuroimaging Initiative (ADNI) and longitudinal plasma data from lecanemab treated individuals evaluated at the Washington University Memory Diagnostic Center (MDC) were also included.；6 For proteins measured using the NULISAseq platform, we applied additional stepwise call rate‐based filtering step, first using a 65% threshold and then an 85% call rate to remove samples and analytes.；[Sensitivity and validation analysis] The SCeNS is a fully data‐driven approach; where there is no need to have a reference group or know the status of the indivudals in the study to be applied, therefore, we conducted a comprehensive series of validation analyses to assess its robustness, stability, and generalizability.；Across all iterations, 500 samples were held constant, while the remaining 1,000 samples were randomly selected from a pool of 1,663 participants with varying proportions of cases and controls.
核心结论
结论：Overall, SCeNS provides an effective tool that allows for the comparison and communication of diverse biological data.
局限
17 , 18 However, advances in measurement platforms have increased dataset heterogeneity, limiting cross‐study integration.
对本项目的价值
★★★★☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。顶刊证据；队列：ADNI；最大样本量约 3,893；设计 系统综述、前瞻队列。
全文来源
PMC JATS 全文（正文 41,997 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Symmetric Centipolar Normalized Score (SCeNS): A standardization framework for fluid marker cross-comparability in Alzheimer's disease.
- 期刊与标识：Alzheimers Dement (Amst) · PMID 42935659 · DOI 10.1002/dad2.70516**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。