数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Dementia, a syndrome marked by impairments in memory, reasoning, and judgment, severely impacts daily functioning and has a significant emotional and economic burden.
方法
This specialized clinic, held every Wednesday in the Geriatric Medicine department of a tertiary care center, focuses on the comprehensive evaluation of patients referred for cognitive decline assessment.；The study was approved by the institutional ethics committee (IEC PG-567/26.09.19), and all participants were provided with comprehensive information about the study and informed consent was obtained from all participants before their inclusion in the study.；For patients with AD, informed consent was obtained from a legally authorized representative (LAR).；[Data collection and procedure] Data collection involved sequential screening, clinical evaluation, and neuropsychological testing of participants, followed by venous sampling for serum NfL estimation.
核心结论
The participants were predominantly male 72.1%. ‖ 结论：These findings support the potential of serum NfL as a non-invasive biomarker for early detection and staging of cognitive decline.
局限
Future studies with balanced gender representation are needed to clarify potential sex-related differences.；This underscores the importance of addressing gender disparities in future research to ensure generalizability [23–25].；However, the proposed ROC-derived cut-offs are preliminary, likely cohort-specific, and should be interpreted as exploratory rather than definitive diagnostic thresholds.
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 129；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 30,669 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Serum neurofilament light protein as a biomarker across the cognitive decline continuum: a cross-sectional study from an Indian cohort.
- 期刊与标识：Aging Clin Exp Res · PMID 42934374 · DOI 10.1007/s40520-026-03381-9**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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