数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Frailty is a geriatric syndrome characterized by reduced physiological reserve and increased vulnerability to stressors, distinct from the normal aging process [1].
方法
KNHANES is a nationwide, population-based survey designed to assess the health and nutritional status of the Korean population using a stratified, multistage probability sampling design.；KNHANES received approval from the KDCA Institutional Review Board for each survey year, and written informed consent was obtained from all participants (approval numbers 2018-01-03-4C-A for 2022 and 2022-11-16-R-03 for 2024).；Of 13,262 total participants in the KNHANES 2022 and 2024 surveys, 3617 were aged ≥65 years.
核心结论
Frailty prevalence was lower in the energy-sufficient group (6.1%) than in the energy-insufficient group (9.5%, p = 0.006).；Overall AMDR adherence did not differ significantly between the energy-sufficient and energy-insufficient groups (29.1% vs.；However, adherence to the carbohydrate and protein AMDRs was higher in the energy-sufficient group (41.2% vs. ‖ 结论：Our findings suggest that both adequate total energy intake and balanced macronutrient distribution are relevant to frailty among older adults.
局限
Differences in how protein intake was defined—by source, unit, and adjustment for energy—likely account for much of this heterogeneity.；First, the cross-sectional design precludes inference regarding temporality or causality, and reverse causation is possible because frailty itself may influence appetite, food preparation capacity, and both the amount and composition of dietary intake.；Sixth, participants excluded because of incomplete frailty data were older and had less favorable socioeconomic, health, and nutritional profiles than those with complete data, suggesting potential selection bias.
对本项目的价值
★★☆☆☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。队列：Rotterdam Study、KNHANES；最大样本量约 2,843；设计 Meta 分析、横断面。
全文来源
PMC JATS 全文（正文 35,643 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Macronutrient Distribution and Frailty According to Energy Sufficiency.
- 期刊与标识：Nutrients · PMID 42942964 · DOI 10.3390/nu18203393**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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