数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Falls are one of the major health problems in older adults [1].
方法
Studies covering a wider age range were eligible only if an analysis restricted to participants aged 60 years and older was presented.；Criterion I3 admitted asymmetry measured either before the occurrence of the outcome or at the same time.；The search was not repeated before submission of the manuscript; consequently, studies published after 2 August 2026 could not be included.；The included studies were checked for multiple reports from the same sample.
核心结论
A single prospective cohort, the Osteoporotic Fractures in Men Study [22], contributed 53% of all participants, and the two largest studies [21,22] together contributed 66%.；Three studies applied threshold values set a priori: 15% in one [37] and 20% in two [31,33].；In the same cohort, by contrast, handgrip strength asymmetry was associated with recurrent falls (relative risk 1.20; 95% CI 1.01–1.43) and with hip fracture (hazard ratio 1.41; 95% CI 1.02–1.96), while handgrip strength asymmetry and lower-limb power asymmetry remained statistically independent (r = 0.01). ‖ 结论：These findings remain limited by the observational nature of the studies and the very low certainty of evidence in all comparisons assessed.
局限
[42], studying 45 older adults with mobility limitation, found that lower-limb power explained 2–8 percentage points more of the variance in functional outcomes than strength in adjusted models.；Persistence of an association after adjustment does not prove causality, and its attenuation does not in itself identify a mechanism.；In such studies, changes in the gait pattern may have preceded a fall, but they may also have been a consequence of injury or activity limitation.
对本项目的价值
★★★★☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。队列：FHS；最大样本量约 27,220；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 104,127 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Association of Lower-Limb Asymmetry with Falls, Physical Performance and Frailty in Older Adults: A Systematic Review.
- 期刊与标识：J Clin Med · PMID 42941710 · DOI 10.3390/jcm15208198**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。