数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Autism spectrum disorders (ASDs) are lifelong neurodevelopmental conditions commonly diagnosed in childhood when afflicted with both restricted and repetitive traits, along with social deficits [1, 2].
方法
The subjects were 213 mice; 36 BTBR T + Itpr3tf/J (BTBR, JAX stock #002282) females weighing (mean ± standard deviation (SD)) 28 ± 4 g and 39 males 34 ± 5 g, 36 each C57BL/6J (C57, JAX stock #000664) females weighting 23 ± 4 g and males 32 ± 5g, and for 129S1/SvImJ (129S, JAX stock #002448) 30 females weighing 22 ± 3 g and 36 males weighing 28 ± 4 g.；All mice were bred in-house from founders originating from Jackson Laboratories (Bar Harbor, ME, USA).；The housing room temperature was between 22 °C and 25 °C with a 14:10 light-dark cycle (300 lux, as measured by the Lux Light Meter Pro App for iOS) on at 0700 h.；All cages contained 2-5 same-sex mice of the same strain with up to a one-week age difference, ad libitum access to chow (Teklad #7912, Harlan, Madison, WI) and water (reverse-osmosis and acidified to a pH of 2.5–3.0 using HCl).
核心结论
For BTBR mice, the two-way ANOVA interaction for time spent in chambers was significant (F (2, 69) = 3.3, p = 0.04). ‖ 结论：For the reduction of restrictive-repetitive behavior, only C57 females buried fewer marbles after acute metformin treatment, while BTBR, 129S, and male C57 mice were unaffected.
局限
First, the small sample size of mice used for behavioral testing may explain why several effects approached but did not reach significance.；Future studies should take this into consideration to determine the wide range of behavioral effects metformin could have.
对本项目的价值
★★★☆☆ 代谢轴既干预敏感性最高，也是老药新用供给最充足的来源。最大样本量约 213。
全文来源
PMC JATS 全文（正文 29,938 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Acute metformin treatment increased social sniffing in male but not female BTBR mice.
- 期刊与标识：Adv Drug Alcohol Res · PMID 42935953 · DOI 10.3389/adar.2026.16883**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
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