数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Aging in males is accompanied by a progressive decline in physical activity, androgen status, and reproductive function.
方法
We investigated whether long-term treatment with the phosphodiesterase type 5 inhibitor sildenafil attenuates these changes and is accompanied by remodeling of mitochondrial homeostasis in the testis.
核心结论
Male rats were treated with low-dose sildenafil from 12 to 18 months of age, with age-matched untreated rats serving as controls and young adult rats providing a reference for the age-associated phenotype.；Aging markedly reduced voluntary locomotor activity, circulating testosterone, and sperm production, while increasing circulating corticosterone.；Long-term sildenafil treatment increased locomotor activity, testosterone, and sperm number, while corticosterone tended to decrease.；Sildenafil-associated body weight changes were observed in animals with access to voluntary running. ‖ 结论：These transcriptional responses differed between cell types, particularly for genes regulating mitochondrial dynamics and quality control.
局限
未能获取全文，具体设计细节、失访与统计学处理无法核验。
对本项目的价值
★★★☆☆ 生殖衰老提供"衰老速率可被激素轴调节"的天然实验窗口。
原文题录
- 英文标题：Long-term sildenafil attenuates age-associated functional and reproductive decline in male rats.
- 期刊与标识：Reproduction · PMID 42937178 · DOI 10.1093/reprod/xaag136**
B 级证据分级：B 级（同行评议临床前研究，主要为动物模型）
本文核心结论来自动物模型或体外细胞学，属临床前证据，不能外推至人体。「延长健康寿命」「改善功能」等表述在小鼠中的意义，与人类临床结局之间仍有距离。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」（SOP §4.2 摘要级）撰写，依据期刊公开摘要与 PubMed 元数据；付费墙全文未获取之处已标注「待补全文」，未做任何数值推算补全。