数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Publications were selected based on the relevance of their titles and abstracts to the aim of this review and their coverage of gut microbiota, gut metabolites, gut-microbiota-brain axis signaling, and AD-related pathological or cognitive phenotypes.
方法
Search Strategy This is a narrative review, and no formal systematic review protocol was implemented.；Conclusions In this study, we reviewed the typical changes in gut microbiota in Alzheimer’s disease and analyzed how altered microbial communities relate to AD progression.
核心结论
Its core pathological features include amyloid-β(Aβ) deposition, abnormal aggregation of Tau protein, and chronic neuroinflammation, which imposes a heavy burden on societies and families worldwide [1].；Search terms included combinations of the following keywords: “gut microbiota”, “gut–microbiota–brain axis”, “Alzheimer’s disease”, “amyloid-β”, “tau”, “cognitive impairment”, “neuroinflammation”, “short-chain fatty acids”, “lipopolysaccharide”, “dysbiosis”, “intestinal permeability”, “microglia”, and “neurodegeneration”.；Specifically, adhering to a healthy diet and regular exercise can theoretically prevent or delay approximately 40% of dementia cases worldwide. ‖ 结论：Our findings add supportive evidence for the microbiota-AD relationship and provide new clues for understanding AD development.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。命中核心 微生物组；设计 RCT、孟德尔随机化。
全文来源
PMC JATS 全文（正文 38,636 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Research Advances and Perspectives on Gut Microbiota Regulating Alzheimer's Disease.
- 期刊与标识：Biology (Basel) · PMID 42939494 · DOI 10.3390/biology15201893**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
本文属观点/评论类文献，不是原始研究。其论点依赖于作者对既有证据的梳理与判断，不构成新的实验证据。本站标注 C 级即为此意——阅读时请把它当作「领域内的思考框架」，而非「研究发现」。
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