数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Although life expectancy has increased, many older adults experience functional decline driven by dysregulation across interconnected biological systems.
方法
Lastly, some of the emerging evidence discussed in this review, including studies evaluating recombinant human LF, is company-associated and has not yet been independently replicated.
核心结论
In osteoblastic and pre-osteoblastic cells, LF reduces apoptosis induced by stress conditions via Wnt5a-dependent activation of cAMP/PKA signaling and stabilization of β-catenin, with partial involvement of PI3K/Akt pathways [52,53]. ‖ 结论：These interconnected systems contribute to chronic low-grade inflammation, oxidative stress, and functional decline.
局限
Future studies are needed to determine whether the mechanistic and biomarker effects of LF translate into clinically meaningful benefits in older adults.；These findings should therefore be interpreted as preliminary and distinguished from independently replicated, peer-reviewed evidence.
对本项目的价值
★★★★☆ 干预证据决定参照标准效应量——任何抗衰干预的收益至少应对标该基线。命中核心 线粒体。
全文来源
PMC JATS 全文（正文 36,142 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Lactoferrin and Healthy Aging: Gut, Immune, Iron, and Mitochondrial Mechanisms.
- 期刊与标识：Nutrients · PMID 42942890 · DOI 10.3390/nu18203319**
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