数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
证据级别：摘要级。本条依据 PubMed 结构化摘要与元数据撰写，付费墙全文未获取、未逐节核验，本站未做任何数值推算补全。
研究问题
Hemocytes are the primary cellular components of the innate immune system in Drosophila melanogaster and share functional and molecular characteristics with vertebrate myeloid cells.
方法
They arise in two developmental waves, an embryonic and a larval wave, and persist through metamorphosis into the adult fly, where they carry out phagocytosis, melanisation, encapsulation, and cytokine signalling.
核心结论
Because hemocytes are in contact with the hemolymph throughout life, they register the nutritional state of the organism through conserved nutrient-sensing pathways, including insulin-like signalling, the target of rapamycin, adipokinetic hormone, and glucose transport.；Signalling through these pathways can influence hemocyte metabolism and function, and hemocyte-derived signals can in turn affect systemic metabolism, fitness, and lifespan.；Growing evidence indicates that these effects are not confined to the exposed individual, since parental and in particular maternal diet can alter hemocyte number, composition, and immune capability in the progeny.；In this review, we discuss the ontogeny of Drosophila hemocytes across the life cycle, their contribution to immune ageing and lifespan, and the nutrient-sensing pathways through which… ‖ 结论：Understanding hemocytes as nutrient-sensing regulators may clarify how diet shapes immune function and survival across generations.
局限
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对本项目的价值
★★★☆☆ 生殖衰老提供"衰老速率可被激素轴调节"的天然实验窗口。
原文题录
- 英文标题：Hemocytes as nutrient-sensing regulators of immune function, lifespan, and intergenerational fitness in Drosophila melanogaster.
- 期刊与标识：Dev Biol · PMID 42946113 · DOI 10.1016/j.ydbio.2026.10.011**
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