数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Ischemic and nonischemic heart disease arise from different initiating injuries but can progress toward shared end-stage myocardial remodeling [1,2].
方法
Human heart tissue samples were obtained from a deidentified cardiac tissue collection established through the long-standing collaboration between Dr.；The collection included failing human left-ventricular myocardium obtained at the time of cardiac transplantation or mechanical circulatory support, as well as nonfailing donor hearts that were unsuitable for transplantation.；The final analysis included 75 samples (20 female and 55 male) after exclusion of one likely duplicate sample.；Samples were processed in two batches, and batch was included in the differential-expression models.
核心结论
At 80% power and a two-sided α of 0.05, the median minimum detectable effect across expressed genes was an absolute log2 fold change of 0.465, corresponding to approximately a 1.38-fold difference.；The interquartile range was 0.256–0.938 in absolute log2 fold change, corresponding to approximately 1.19- to 1.92-fold differences. ‖ 结论：These etiology-associated differences should be considered exploratory because they did not remain significant after FDR correction.
局限
Nominal findings from the direct disease, sex, and race comparisons should be considered hypothesis-generating and require further replication.；Although batch was included as a covariate and the Batch-1-only sensitivity analysis showed substantial directional concordance with the full batch-adjusted analyses, the unbalanced design may limit complete separation of technical and biological effects.
对本项目的价值
★★☆☆☆ 血管老化提供可影像量化、可短期读取的中间终点，适合做机制到临床的桥接。最大样本量约 10；设计 多组学。
全文来源
PMC JATS 全文（正文 34,475 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Immune-Inflammatory, Autophagy, and JNK Remodeling in Ischemic and Nonischemic Human Myocardium.
- 期刊与标识：Curr Issues Mol Biol · PMID 42939620 · DOI 10.3390/cimb48101082**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。