数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Age-related macular degeneration (AMD) is one of the leading causes of irreversible visual impairment and blindness among older adults and represents a major global public health concern.
方法
A global systematic review and meta-analysis published in 2014 estimated that, among individuals aged 45–85 years, the prevalence of early AMD, late AMD, and all AMD was 8.0%, 0.37%, and 8.7%, respectively, corresponding to an estimated global population of approximately 196 million individuals with AMD in 2020 [1].；As a narrative review, this article was based on a targeted literature search and critical selection of relevant publications rather than a systematic review methodology.；In this review, diesel exhaust is not considered an independently established risk factor for AMD but rather as a complex oxidative stress-inducing exposure within the broader spectrum of traffic-related air pollution.；A systematic review examining multiple air pollutants, including PM2.5, PM10, NO2, O3, and SO2, identified relatively few studies evaluating SO2 in relation to AMD, precluding firm conclusions regarding the strength or consistency of this association [24].
核心结论
A global systematic review and meta-analysis published in 2014 estimated that, among individuals aged 45–85 years, the prevalence of early AMD, late AMD, and all AMD was 8.0%, 0.37%, and 8.7%, respectively, corresponding to an estimated global population of approximately 196 million individuals with AMD in 2020 [1].；In a longitudinal study of 39,819 individuals in Taiwan, long-term exposure to NO2 and CO was associated with an increased risk of incident AMD, with individuals in the highest exposure categories showing approximately 1.9-fold and 1.8-fold higher risks, respectively, than those in the lowest exposure categories [19].；These findings highlight the importance of evaluating environmental chemical exposures not only individually but also as co-exposures, because simultaneous exposure to multiple toxicants may produce additive, synergistic, or otherwise interactive biological… ‖ 结论：Moving toward exposure-informed, mechanism-based, and biomarker-guided prevention is a reasonable direction for future AMD research, but its clinical value remains to be demonstrated.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★★★☆ 线粒体端点既是机制解释层，也是最容易拿到体外 / 影像读数的中间层。命中核心 线粒体；队列：UK Biobank、NHANES；最大样本量约 624,167；设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 144,341 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：The Environmental Exposome and Age-Related Macular Degeneration: Oxidative Stress as a Molecular Link.
- 期刊与标识：Antioxidants (Basel) · PMID 42939925 · DOI 10.3390/antiox15101351**
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