数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Progressive cognitive decline is one of the major concerns associated with mild cognitive impairment and dementia (Knopman and Petersen, 2014), making its accurate measurement and prediction a core objective in research on cognitive aging and neurodegenerative disease.
方法
To be eligible for participation, participants had to be between 40 and 65 years old at the start of the study and, as determined by the initial screening, had no history of neurological or psychiatric conditions (Cattaneo et al., 2020).；The present analysis included all individuals who completed the full neuropsychological test battery at baseline assessment (2018–2019) and at the two follow-up waves (2020–2022 and 2025).；Among 973 participants with a valid baseline cognitive assessment, 442 completed the full neuropsychological battery at all three waves and constituted the present analytic sample.
核心结论
The analytic sample included 442 cognitively healthy adults (mean age = 51.2 years, SD = 5.5; 50.7% women; mean education = 17.2 years, SD = 3.6).；[Retest-related effects and global cognit] In the global cognition model, both retest-related indicators were significant (Wave 2: β = 0.270, p < 0.001; Wave 3: β = 0.363, p = 0.017), indicating additional increases in global cognition at follow-up consistent with retest-related practice effects.；Greater memory practice effect was associated with higher overall global cognitive performance across waves (β = 0.121, p = 0.0008) and was significantly associated with estimated longitudinal change in global cognition (β = 0.011 per year, p = 0.002). ‖ 结论：In conclusion, the present findings indicate that episodic memory practice effects may capture variation not fully attributable to generic retest-related gains.
局限
This complete-case approach may have introduced selection bias.；Accordingly, some degree of selection bias may remain, and the younger age of the retained sample may limit the generalizability of the findings to older individuals from the original baseline cohort.；Future work should evaluate whether the measurement structure remains stable across repeated assessments.
对本项目的价值
★★★☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。最大样本量约 973；设计 系统综述、前瞻队列。
全文来源
PMC JATS 全文（正文 39,482 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Beyond retest gains: episodic memory practice effects and longitudinal cognitive trajectories in cognitively healthy adults.
- 期刊与标识：Front Aging Neurosci · PMID 42935649 · DOI 10.3389/fnagi.2026.1933991**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
关于本文的文献来源：本站依据 IMA 知识库「五刊监控·深度文献卡片」撰写，依据已获取的期刊全文（方法、样本量与结论已回到原文核对）；未能获取全文的同批条目另行标注「摘要级」，全程未做任何数值推算补全。