数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Neurodegenerative diseases are a heterogeneous group of disorders characterized by the progressive loss of neuronal structure and function, resulting in cognitive decline, motor impairment, and reduced independence.
方法
Review Type and Literature Search Strategy This article is a narrative review, not a systematic review or scoping review.；We searched PubMed/MEDLINE, Web of Science, and Scopus from database inception to 31 August 2026.
核心结论
In addition to 5mC, genome-wide profiling of postmortem human brain tissue has identified differentially hydroxymethylated regions associated with amyloid-β and tau pathology.；Therefore, when this regulatory process is disordered, it may participate in amyloid-β (Aβ) deposition, tau pathology, synaptic damage and AD-related pathological processes such as inflammation.；Integrated accessibility and transcriptomic profiling, followed by targeted perturbation and rescue experiments, is therefore needed to distinguish pathogenic regulation from compensatory responses or secondary consequences of neuronal injury. ‖ 结论：Clinical studies should evaluate molecular responses alongside clinically meaningful cognitive, functional, or survival outcomes, while specifying the patient populations to which their findings can be applied.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。设计 Meta 分析、系统综述。
全文来源
PMC JATS 全文（正文 91,919 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Epigenetic Mechanisms in Neurodegenerative Diseases: From Genetic Regulation to Therapeutic Potential.
- 期刊与标识：Int J Mol Sci · PMID 42942089 · DOI 10.3390/ijms27209322**
C 级证据分级：C 级（预印本 / 观点评论，非原始研究）
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