数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
However, measuring clinical frailty alongside multi-omics profiles remains limited, preventing the ability to understand ‘biological aging’ and ‘inflammaging.’ [21,22].
方法
This is a cross-sectional analysis of baseline blood markers and physical function data collected as part of a 12-week prospective pilot study evaluating a physical therapy intervention, conducted at the University of North Carolina at Chapel Hill (UNC) Geriatric Specialty Clinic between June 2022 and March 2023.；All participants provided written consent in accordance with the University of North Carolina at Chapel Hill (UNC) Institutional Review Board (IRB), study #22-1230.；Participants were eligible if they were ≥65 years of age, currently being cared for at the Geriatrics clinic, had at least two chronic medical conditions, and were referred by their clinical provider to a 12-week community- or university-based physical therapy (PT) program.；Key exclusion criteria included life-threatening illnesses, or untreated psychiatric conditions that could interfere with participation, dementia, participation in another PT program, scheduled surgery in the next six months, or any of the following comorbidities due to risk of being unable to participate in the PT intervention:…
核心结论
Mean ± SD age was 77.1 ± 5.5 years (33% female), with a mean of 2.6 ± 2.0 comorbidities per participant in this highly educated cohort.；Twelve (66.7%) were classified as pre-frail and 6 (33.3%) as frail using the CDI; there were no robust participants categorized.；Stratifying by the Fried Index, there were 6 patients (33.3%) classified as robust, 7 (38.9%) as pre-frail, and 5 (27.8%) as frail. ‖ 结论：This study suggests that DNA/histone-associated markers and nicotinamide—a precursor in NAD+ metabolism—may be associated with frailty.
局限
Our exploratory findings suggest several candidate metabolomic and proteomic markers that may warrant further investigation across the frailty spectrum.；Given our cross-sectional design and small sample size, these should be interpreted as hypothesis-generating rather than as establishing a biological basis for frailty.；This should be interpreted as a hypothesis-generating signal only, given our small sample size and cross-sectional design.
对本项目的价值
★★★★☆ 衰弱/肌少症是少有的已有监管认可终点的老年综合征，是临床转化的最短路径。命中核心 NAD⁺轴；最大样本量约 18；设计 前瞻队列、横断面。
全文来源
PMC JATS 全文（正文 42,477 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Association of Frailty Status with Semi-Targeted Metabolomics and Untargeted Proteomics in Older Adults Referred for Physical Therapy in a Geriatric Clinic.
- 期刊与标识：Nutrients · PMID 42942907 · DOI 10.3390/nu18203336**
A 级证据分级：A 级（同行评议人体研究）
本文属人体研究证据，但需注意：观察性或小样本干预的结论不等于已证实临床获益；效应量与长期安全性仍需更大规模、更长随访的试验验证。
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