数据日期 2026-10-29 · 生成时间 2026-10-29 06:03
研究问题
Alzheimer’s disease (AD) is the most prevalent form of dementia and a leading cause of disability and death in older adults worldwide [1].
方法
The mechanisms discussed in this review should not be considered independently.；Aβ-associated microglial responses can involve NLRP3 activation, caspase-1-dependent maturation of IL-1β and IL-18, gasdermin-mediated pyroptosis, and altered iron metabolism [54], but these processes have not been directly examined for the circRNAs discussed in this review.
核心结论
The neuropathological features of AD are extracellular plaques containing aggregated Aβ (amyloid-β), generated through sequential β- and γ-secretase cleavage of APP (amyloid precursor protein), and intraneuronal neurofibrillary tangles composed of hyperphosphorylated tau [7,8].；In the pivotal CLARITY AD trial, lecanemab slowed decline on the Clinical Dementia Rating–Sum of Boxes (CDR-SB) by 27% over 18 months in participants with mild cognitive impairment or mild AD dementia [100].；A notable recent shift, however, has been the emergence of non-invasive, blood-based biomarkers that avoid the procedural burden of lumbar puncture and the cost and accessibility limitations of PET imaging—exemplified by plasma p-tau217, which distinguishes pathologically confirmed AD from non-AD with an AUC of 0.88–0.90 and may rise up to 20 years before mild cognitive impairment onset in inherited AD [37]. ‖ 结论：These models could then determine whether circRNA-dependent effects identified in individual cell types are maintained in a human multicellular environment.
局限
全文未设独立 limitations 节；结构上为综述/二次研究，因果推断强度受限。
对本项目的价值
★★☆☆☆ 脑老化是最大未满足需求，也是终点最难量化的领域；biomarker 与认知读数选择最敏感。
全文来源
PMC JATS 全文（正文 111,647 字符，已过标题/DOI 逐字归属校验）
原文题录
- 英文标题：Circular RNAs in Alzheimer's Disease: Mechanisms, Biomarkers, and EPAC Signalling in Ferroptosis.
- 期刊与标识：Antioxidants (Basel) · PMID 42939895 · DOI 10.3390/antiox15101321**
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