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A recent study using an animal model showed that at nonphysiological oxygen levels (~20% O2), mouse embryos exhibited reduced telomere elongation duri…

Telomerase activity is usually low or undetectable in most normal somatic cells, whereas it is detected in most human cancers (up to 90%), where it su…

In this review, we examine how TDP-43 dysfunction disrupts lineage-specific glial homeostatic programs and promotes distinct pathological state transi…

1.08 μmol/g, respectively), which translates to a 15-fold increase in glucoraphanin content between these two forms of broccoli [29].；In a human kinet…

The young stem cell-transplanted mice exhibited a 16% increase in lifespan.；The results showed that the BMSC-transplanted mice had an average extensio…

The 2024 Lancet Commission estimated that addressing 14 modifiable factors, including depression and social isolation, could prevent or delay up to 45…

At the signaling level, peri- cyte contractility is regulated by multiple mediators, including platelet-derived growth factor-β (PDGF-β) and adenosine…

Early-phase SASP is characterized by secretion of transforming growth factor-β (TGF-β), chemokines, and pro-inflammatory cytokines.；When TGF-β signali…

Cellular senescence is itself heterogeneous: p16 and p21 expression, SA-β-gal activity, and SASP components vary across cell types, tissues, and senes…

结论：Overall, SCeNS provides an effective tool that allows for the comparison and communication of diverse biological data.

Histological and in vivo imaging studies have consistently demonstrated that retinal ganglion cells (RGCs) decline at an annual rate of approximately …

Mitochondria are the principal sites of ATP production in cells, supplying over 90% of cellular energy requirements (21).；This intervention restores A…

The proteostasis network is a fundamental functional unit in biology with relevance to many diseases.；Despite its importance, the human proteostasis n…

Recent analyses suggest that approximately 25–30% of tissue-enriched proteins, including those derived from skeletal muscle, can be detected in plasma…

In mammalian cells, endogenous H2S is primarily synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and the coupled cysteine a…

Within the U.S., approximately 13–15% of children aged 2–5 years have obesity [93] and about 23% of adolescents aged 12–19 years are affected [94].；In…

结论：These include the early detection of individuals at risk, identification of AD onset in patients with subjective cognitive impairment or mild cogni…

In particular, a novel topical formulation containing niacinamide, arbutin, tranexamic acid, ubiquinone, a DHEA-like component, curcuma extract, and m…

In a seminal experimental study, AChE was shown to accelerate the assembly of amyloid-β (Aβ) peptides into fibrils, whereas this effect was reduced by…

This review examines hypotheses of the pathogenesis of AD, including the involvement of amyloid-β peptide and hyperphosphorylated tau protein fragment…

Much of this effect of PTPRD is likely to result from its role in modulating the neuronal activities of the key tau hyperphosphorylating kinases, glyc…

However, advances in the understanding of OA pathogenesis have led to the emergence of therapeutic strategies targeting metabolic dysfunction, inflamm…

Significant heterogeneity was observed across the studies (P < .00001, I2 = 97%).；Similarly, significant heterogeneity was noted across these studies …

Studies developing or validating oral frailty assessment instruments in older adults were included.；Clinical measures were summarized descriptively.；P…