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← 返回分级说明Three generations of epigenetic clocks (Horvath, Hannum, PhenoAge, GrimAge, DunedinPACE), transcriptomic markers of cellular senescence (p16INK4a, mTO…
Recent clinical studies have revealed that OL dysfunction and white matter changes occur at an early stage of Parkinson's disease (PD) and may be asso…
However, persistent nutritional restraint could eventually become disadvantageous if nutritional and physiological reserves become insufficient as ind…
Pairwise Meta-Analysis] For muscle mass, pooled results from nine studies showed that, compared to control, nutritional interventions significantly im…
Searches were conducted in PubMed, CINAHL, and Scopus.；Randomised controlled trials explicitly defining frailty were eligible.；Two reviewers independe…
[35] found acalculia in 25 of 39 patients (64%), with poorer calculation associated with reduced left angular gyrus perfusion. ‖ 结论：Future studies usi…
结论：Therefore, the main translational question is not whether TCM-derived bioactive compounds can reduce inflammatory markers in experimental models, b…
No meta-analysis, formal risk-of-bias assessment, or certainty-of-evidence grading was undertaken.；The nonrandom allocation and 25% overall attrition …
Initially, a comprehensive domain-wide search was performed using the following query string: (“Alzheimer disease” OR “AD”) AND (“amyloid β-protein” O…
This combined approach revealed that extracellular amyloid-β (Aβ) plaques induce highly localized pre-synaptic toxicity and dystrophic neurites strict…
Multifactorial Mechanisms of Skeletal Muscle Dysfunction in COPD Not all COPD patients develop skeletal muscle dysfunction; approximately 40% show sig…
Introduction Alzheimer’s disease (AD) is a complex neurodegenerative disorder in which amyloid-β (Aβ) deposition, abnormal tau phosphorylation, neuroi…
Introduction AD is the most common cause of dementia, accounting for approximately 60–70% of all cases worldwide.；It is estimated that around 10% of i…
The typical pathological changes in AD include amyloid plaques formed by the deposition of β-amyloid (Aβ) (Glenner and Wong, 1984; Masters et al., 198…
GLP-1RA-induced weight loss is associated with 25–39% of total lost mass being lean tissue [10], as suggested by data published in several clinical tr…
Changes in expression levels of senescent markers Senescence-associated β-galactosidase (SA-β-gal) is widely recognized as a prevalent indicator of ce…
Particular emphasis is placed on sirtuin 1 (SIRT1) and sirtuin 3 (SIRT3) across the heart, liver, adipose tissue, skeletal muscle and pancreatic β-cel…
A single prospective cohort, the Osteoporotic Fractures in Men Study [22], contributed 53% of all participants, and the two largest studies [21,22] to…
Of these, 36% (9/25) were observational studies (incorporating both cross-sectional and longitudinal designs), while the remaining 64% were experiment…
The studies were conducted primarily in the United States (n = 9, 36%) (Agbavor and Liang, 2022; Guan et al., 2025; Huang et al., 2025; Kearney et al.…
Introduction Laminins are heterotrimeric glycoproteins assembled from five α chains (α1–α5), three β chains (β1–β3), and three γ chains (γ1–γ3).；The t…
In osteoblastic and pre-osteoblastic cells, LF reduces apoptosis induced by stress conditions via Wnt5a-dependent activation of cAMP/PKA signaling and…
Pathophysiologically, AD was traditionally defined as a continuum of neurodegenerative processes driven by the accumulation of amyloid-β (Aβ) plaques …
In addition to amyloid-β and tau pathology, the disease is shaped by inflammation, vascular injury, aging biology, metabolic dysfunction, and host-mic…