预印本（未经同行评议）
发布在 bioRxiv、medRxiv 等预印本平台的论文，尚未经过同行评议。此类结论可能随审稿意见而改变，仅供领域跟踪参考。
如何解读这一层级
⚠️ 本站对所有预印本内容均显式标注「未经同行评议」。预印本不应作为决策依据，引用时须注明其未同行评议的状态。
全部文章 · 第 14 页
← 返回分级说明Beyond their baseline anti-inflammatory efficacy, HDACis possess significant therapeutic value in oncology by preventing chimeric antigen receptor T-c…
（原文未设独立引言节）
The proteostasis network is a fundamental functional unit in biology that is essential for cellular health and has direct relevance to many diseases o…
This Review examines how canonical histone modifications and emerging metabolite-derived acylations regulate inflammatory and stress-responsive progra…
Experimental models have shown that recurrent HSV-1 infection and reactivation can induce several AD-associated pathological features, including amylo…
Because hemocytes are in contact with the hemolymph throughout life, they register the nutritional state of the organism through conserved nutrient-se…
Its core pathological features include amyloid-β(Aβ) deposition, abnormal aggregation of Tau protein, and chronic neuroinflammation, which imposes a h…
ROS, mitochondrial damage, LPS, and other microbial signals can activate NLRP3 inflammasomes, caspase-1, gasdermin D, and release of IL-1 β and IL-18 …
Bacterial β-glucuronidases can deconjugate estrogen glucuronides in the intestine, facilitating reabsorption and potentially influencing systemic estr…
About 50% of Long COVID patients are generally believed to meet the diagnostic criteria for ME/CFS, with high degrees of overlap [1,2].；At only 2% of …
Suppression of clearance of toxic waste following deletion of AQP4 is further supported by the slowing down of CSF influx by almost 70% [1]. ‖ 结论：Thes…
The evidence base remained markedly uneven: sixteen studies (61.5%) investigated MS/EAE, seven (26.9%) investigated PD, two (7.7%) addressed AD-relate…
The pooled random-effects estimate showed no evidence of a treatment effect (Hedges’ g = 0.014, 95% CI: −0.061 to 0.088; p = 0.515), with tau2 = 0 and…
新登记于 2026-10-27 的 NCT07898839：15 人、Phase 2，用 N-乙酰半胱氨酸、α-硫辛酸、烟酰胺核糖与二甲双胍缓释片组合加研究膳食，检验双硫死亡在胆汁疾病中的作用。
In addition to 5mC, genome-wide profiling of postmortem human brain tissue has identified differentially hydroxymethylated regions associated with amy…
A global systematic review and meta-analysis published in 2014 estimated that, among individuals aged 45–85 years, the prevalence of early AMD, late A…
Introduction Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–70% of cases worldwide [1].；The developmen…
The defining pathological hallmarks of AD are extracellular amyloid plaques formed by amyloid-β (Aβ) deposition and intracellular neurofibrillary tang…
To systematically map and evaluate the evidence on whether dental care utilization and specific dental interventions are associated with cognitive fun…
Four [31–33] cohorts AUC estimates were included in the short follow-up subgroup, with a pooled AUC of 0.71 (95% CI 0.65–0.77).；Eight [31–36] were inc…
The expected amount of furfural formed by C5 hydroxylation relative to 5-methylene-2-furanone (C1 hydroxylation) is 15%.；The only existing data indica…
结论：The goal is not to force maximal ubiquitination or autophagy, but to restore the timing and selectivity with which healthy cells detect, contain, a…
Sporadic AD, which constitutes approximately 95% of all cases, typically manifests after the age of 65 and is referred to as late-onset AD (LOAD)5.；Cu…
Work in Drosophila establishes that insulin signaling is allatotropic - it stimulates the production and secretion of JH from the corpora allata.；JH t…