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综述解读 C 2026-10-29 生命历程

The union of the five original exports retrieved all 33 final included reports (100%), although no single database was complete.;Overall, two trials (…

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The neuropathological features of AD are extracellular plaques containing aggregated Aβ (amyloid-β), generated through sequential β- and γ-secretase c…

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Specifically, European Union countries estimate a 58% rise in dementia cases between 2025 and 2050 [2].;Among dementia types, Alzheimer’s disease is t…

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Most studies were retrospective (91.2%, n = 31) and 7 (20.6%) were multicenter.;Twenty-one studies (61.8%) originated from Eastern countries—10 from C…

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Although its pathophysiology is strongly associated with pancreatic β-cell dysfunction and altered metabolism in the liver, skeletal muscle, and adipo…

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Up to 20–30% of PCA presentations were driven by non-AD pathologies, including Lewy body disease, corticobasal degeneration, or prion disease [150,151…

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In addition, NF-κB regulates proinflammatory molecules, including CCAAT-binding protein β (C/EBPβ), bromodomain-containing protein 4 (BRD4), lysine me…

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With its advantages of minimal invasiveness, convenience, affordability, and high accessibility, blood-based testing has overcome the limitations of c…

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Additional sensitivity analyses addressing potential population overlap among studies derived from the Taiwan NHIRD showed that the pooled association…

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结论:This article aimed to shed light on how AI accelerates the clinical implementation of biological age rather than chronological age in precision med…

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In bloodstream infections caused by P. aeruginosa, carbapenem resistance is an independent predictor of mortality, with a pooled attributable mortalit…

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A cumulative predicted implantation probability above 60% has been proposed as the threshold for further work-up (1).;A meta-analysis found modestly h…

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A widely cited systematic review estimated an overall prevalence of 16.7% by combining autopsy and radiological series (14.4% and 22.5%, respectively)…

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Finally, although their short generation times and lifespans allow quick data collection, short-lived organisms may exhibit a much greater capacity fo…

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Introduction As a central energy status sensor in eukaryotic cells, AMPK orchestrates metabolic homeostasis through its heterotrimeric complex compris…

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