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← 返回分级说明The union of the five original exports retrieved all 33 final included reports (100%), although no single database was complete.;Overall, two trials (…
The neuropathological features of AD are extracellular plaques containing aggregated Aβ (amyloid-β), generated through sequential β- and γ-secretase c…
Specifically, European Union countries estimate a 58% rise in dementia cases between 2025 and 2050 [2].;Among dementia types, Alzheimer’s disease is t…
Its components include pro-inflammatory cytokines such as interleukin-1 alpha (IL-1α), interleukin-1 beta (IL-1β), IL-6, IL-8, and tumor necrosis fact…
Most studies were retrospective (91.2%, n = 31) and 7 (20.6%) were multicenter.;Twenty-one studies (61.8%) originated from Eastern countries—10 from C…
Although its pathophysiology is strongly associated with pancreatic β-cell dysfunction and altered metabolism in the liver, skeletal muscle, and adipo…
Up to 20–30% of PCA presentations were driven by non-AD pathologies, including Lewy body disease, corticobasal degeneration, or prion disease [150,151…
In addition, NF-κB regulates proinflammatory molecules, including CCAAT-binding protein β (C/EBPβ), bromodomain-containing protein 4 (BRD4), lysine me…
With its advantages of minimal invasiveness, convenience, affordability, and high accessibility, blood-based testing has overcome the limitations of c…
Additional sensitivity analyses addressing potential population overlap among studies derived from the Taiwan NHIRD showed that the pooled association…
结论:This article aimed to shed light on how AI accelerates the clinical implementation of biological age rather than chronological age in precision med…
In bloodstream infections caused by P. aeruginosa, carbapenem resistance is an independent predictor of mortality, with a pooled attributable mortalit…
A cumulative predicted implantation probability above 60% has been proposed as the threshold for further work-up (1).;A meta-analysis found modestly h…
A widely cited systematic review estimated an overall prevalence of 16.7% by combining autopsy and radiological series (14.4% and 22.5%, respectively)…
Finally, although their short generation times and lifespans allow quick data collection, short-lived organisms may exhibit a much greater capacity fo…
Introduction As a central energy status sensor in eukaryotic cells, AMPK orchestrates metabolic homeostasis through its heterotrimeric complex compris…
一份概念框架要求候选抗原在同一细胞情境下同时满足四条标准,且采用「一票否决」规则;用它检验 uPAR 与 GPNMB,两者目前均未达标。
【摘要级】重复 VU0155069 处理与雌性 3xTg-AD 小鼠中区域及病理阶段特异的树突棘重塑相关
【摘要级】Genedex:在阿尔茨海默病病理、细胞类型与脑区之间为基因签名建立语境
【摘要级】老年人表现出保留的视听整合神经签名,但其与言语理解的关联发生改变
【摘要级】更进一步:C57BL/6 小鼠自主运动的多维运动与步态模式的年龄及性别依赖性变化
【摘要级】基于正则化逻辑回归的基因选择用于肌肉衰老与再生中异质性 scRNA-seq 巨噬细胞群的功能分析
【摘要级】习惯性睡眠时长与脑网络可控性的皮层组织相关
【摘要级】核纤层相关结构域内的 DNA 损伤触发核膜重组与染色质脱离,以防止核膜出泡与基因组不稳定