神经退行性疾病
阿尔茨海默病、帕金森病、认知衰退与神经再生。神经系统退化是衰老研究投入最大的领域之一。
全部文章 · 第 10 页
← 返回专辑索引With its advantages of minimal invasiveness, convenience, affordability, and high accessibility, blood-based testing has overcome …
Up to 20–30% of PCA presentations were driven by non-AD pathologies, including Lewy body disease, corticobasal degeneration, or pr…
Of these almost 95% (n = 3095) completed the baseline assessment.；The cohort is predominantly of white ethnicity (98.9%), 59.9% fe…
Here, we identify a dynamic interplay between cellular vulnerability and circuit-level resilience that shapes cognitive outcomes i…
Here, we show that full-body Cass4 deletion in 5xFAD mice increases amyloid-β (Aβ) deposition, neuronal dystrophy, and cognitive d…
No significant group differences were observed in age (p = 0.150), gender distribution (p = 0.818) and education duration (p = 0.3…
Consistent with age‐related declines in fitness, VO2peak was significantly greater in middle‐aged adults compared to older adults,…
Female C57BL/6J mice aged 6 or 18 months at study onset were fed either normal food (NF) or cuprizone (0.2%) mixed into the diet f…
Specifically, European Union countries estimate a 58% rise in dementia cases between 2025 and 2050 [2].；Among dementia types, Alzh…
72 名认知未受损老年人单盲随机对照，训练组 30 分钟/天、每周 5 天、共 12 周；双侧毯部与右侧丘脑后辐射的 FA 下降显著小于对照，PAL 情景记忆改善（P=.04）。
The neuropathological features of AD are extracellular plaques containing aggregated Aβ (amyloid-β), generated through sequential …
The 10 µM cisplatin caused approximately 70% of IHCs and 71% of OHCs to disappear, with statistically significant loss in both two…
Sporadic AD, which constitutes approximately 95% of all cases, typically manifests after the age of 65 and is referred to as late-…
The prediction showed an average structural similarity of 70.82% and a prediction accuracy of 69.26%, suggesting a moderate-to-goo…
Four [31–33] cohorts AUC estimates were included in the short follow-up subgroup, with a pooled AUC of 0.71 (95% CI 0.65–0.77).；Ei…
To systematically map and evaluate the evidence on whether dental care utilization and specific dental interventions are associate…
The defining pathological hallmarks of AD are extracellular amyloid plaques formed by amyloid-β (Aβ) deposition and intracellular …
The mean age was 84.62 years (SD, 10.80), with 21.0% of participants aged 65 to 74 years, 31.2% aged 75 to 84 years, 36.0% aged 85…
[Convergent validity of WML volume] BAAD‐derived WML volume (from T1) agreed with the visual ratings from the independent FLAIR im…
Protein–ligand heteroatom distances of ≤3.5 Å were observed in 8.6% of analyzed frames, while distances of ≤4.0 Å occurred in 57.0…
结论：Collectively, the present study demonstrates that pharmacological enhancement of endogenous 2-AG signaling through inhibition o…
Introduction Alzheimer’s disease (AD) is the most common cause of dementia, accounting for approximately 60–70% of cases worldwide…
Of note, the improvement rate was between 15% and 30% in Patient 9 during the levodopa challenge test, whereas all other patients …
In addition to 5mC, genome-wide profiling of postmortem human brain tissue has identified differentially hydroxymethylated regions…