神经退行性疾病

The analytic sample included 442 cognitively healthy adults (mean age = 51.2 years, SD = 5.5; 50.7% women; mean education = 17.2 y…

The pooled random-effects estimate showed no evidence of a treatment effect (Hedges’ g = 0.014, 95% CI: −0.061 to 0.088; p = 0.515…

The first principal component accounted for 26.86% of the total expression variance, whereas the second principal component accoun…

Solid arrows indicate significant associations (P < 0.05); dashed arrows, non-significant. ‖ 结论：The present study demonstrated tha…

The evidence base remained markedly uneven: sixteen studies (61.5%) investigated MS/EAE, seven (26.9%) investigated PD, two (7.7%)…

Suppression of clearance of toxic waste following deletion of AQP4 is further supported by the slowing down of CSF influx by almos…

About 50% of Long COVID patients are generally believed to meet the diagnostic criteria for ME/CFS, with high degrees of overlap […

Its core pathological features include amyloid-β(Aβ) deposition, abnormal aggregation of Tau protein, and chronic neuroinflammatio…

Using all available proxies, higher genetically predicted anti-H. pylori IgG seropositivity was associated with lower risk of Alzh…

结论：In conclusion, HDL functional properties, specifically their capacity to remove excess cholesterol from neurons and to protect …

Age (F = 13.42, p < 0.001), sex (χ2 = 20.79, p < 0.001), and APOE ε4 carrier status (χ2 = 23.61, p < 0.001) all differed significa…

In AD-F mice, DHA and NR treatment also trended toward improved memory compared to AD fed chow, but the difference in latency was …

This ecological study examined country-level associations be-tween average household size and modelled neurological disease incide…

Block-based statistical analysis of total MM-PBSA energies revealed no significant difference between SIRT1–4TQ and SIRT1–IA (p = …

In addition to amyloid-β and tau pathology, the disease is shaped by inflammation, vascular injury, aging biology, metabolic dysfu…

(D) Analysis of the percentage of the population that was labeled showed that CLD delivered antibody into approximately 65% of the…

Pathophysiologically, AD was traditionally defined as a continuum of neurodegenerative processes driven by the accumulation of amy…

Brain lipid deposition, plasma and brain TC, TG and NEFA levels, and expressions of BACE1, Aβ, p-Tau, ZO-1, occludin, AMPK/p-AMPK,…

Cox proportional hazards regression showed no significant main effect of sex on survival (hazard ratio (HR) = 0.43, p = 0.25). ‖ 结…

结论：In conclusion, these findings identify miRNAs in L1CAM-enriched EVs as candidates for further investigation as minimally invasi…

The studies were conducted primarily in the United States (n = 9, 36%) (Agbavor and Liang, 2022; Guan et al., 2025; Huang et al., …

The mean age of the cohort was 69.54 years (SD = 8.66); 61.9% were female, and 56.6% were APOE ε4 carriers. ‖ 结论：The study protoco…

Of these, 36% (9/25) were observational studies (incorporating both cross-sectional and longitudinal designs), while the remaining…

Both attenuated after adjustment for age, sex and education, and only the Digit Span Backward association remained nominally signi…