神经退行性疾病

Parallel-process latent growth curve models examined level and change associations; additional analyses evaluated hearing-aid mode…

Melatonin, a pleiotropic neuroprotective molecule with antioxidant, anti-inflammatory, and anti-apoptotic properties, has emerged …

The typical pathological changes in AD include amyloid plaques formed by the deposition of β-amyloid (Aβ) (Glenner and Wong, 1984;…

Here we show that NgBR is highly expressed in microglia, where its deficiency drives progressive PD-like motor deficits and dopami…

Introduction AD is the most common cause of dementia, accounting for approximately 60–70% of all cases worldwide.；It is estimated …

This combined approach revealed that extracellular amyloid-β (Aβ) plaques induce highly localized pre-synaptic toxicity and dystro…

Initially, a comprehensive domain-wide search was performed using the following query string: (“Alzheimer disease” OR “AD”) AND (“…

No meta-analysis, formal risk-of-bias assessment, or certainty-of-evidence grading was undertaken.；The nonrandom allocation and 25…

More than half of the participants (53.42%, n = 86) had completed at least 12 years of education.；Notably, more than half of the p…

[35] found acalculia in 25 of 39 patients (64%), with poorer calculation associated with reduced left angular gyrus perfusion. ‖ 结…

Although ovarian tumor protease deubiquitinase 1 (OTUD1) participates in various biological processes, its specific functions in P…

Recent clinical studies have revealed that OL dysfunction and white matter changes occur at an early stage of Parkinson's disease …

衰老小鼠脑内 8-oxoGTP 累积；单独升高就足以造成突触功能障碍、tau 过度磷酸化、神经元丢失与认知下降，机制是它比 GTP 更强地激活 G 蛋白。

Moreover, support for several steps (MAC1/NOX2, HMGB1/TREM2, lipid peroxidation by-products, gut–brain signaling) comes from non-o…

Much of this effect of PTPRD is likely to result from its role in modulating the neuronal activities of the key tau hyperphosphory…

APOE ε4 carrier frequency increased across the clinical groups, from 30.7% in CN to 50.0% in MCI and 71.3% in AD dementia (p < 0.0…

Under identical conditions, the reference inhibitor roflumilast (0.1 nM) reduced activity to 43.2 ± 6.5%.；Survival rates at 168 hp…

A systematic review of clinical studies demonstrates that a significant proportion of patients with partial edentia remain without…

Hindlimb-supported standing time was significantly reduced in aged mice (3.75 ± 0.25 s, N = 4) compared with young mice (10.8 ± 2.…

Regression lines and 95% CI (shaded areas) are presented for binarized groups defined by pPRS < 25th percentile (blue, “Low pPRS”)…

This review examines hypotheses of the pathogenesis of AD, including the involvement of amyloid-β peptide and hyperphosphorylated …

In a seminal experimental study, AChE was shown to accelerate the assembly of amyloid-β (Aβ) peptides into fibrils, whereas this e…

In an earlier issue of JGP, Hariharan et al.；(https://doi.org/10.1085/jgp.202614014) significantly add to our understanding of thi…

PVS were automatically quantified in basal ganglia, centrum semiovale, hippocampus, and midbrain on 3T MRI.；Counts were modelled u…