神经退行性疾病

Each point represents an individual biomarker effect estimate (beta) and error bars represent the corresponding 95% confidence int…

Primary analyses focused on relationships between plasma β-synuclein and synaptic density, and associations with related plasma bi…

结论：These include the early detection of individuals at risk, identification of AD onset in patients with subjective cognitive impa…

The mean planning latency in patients with fibromyalgia (11,985 (915) ms) was not significantly different from that in the control…

80.8 ± 7.4 years, p < 0.001) and had a higher burden of age-related comorbidities.；11.9%), chronic obstructive pulmonary disease (…

In mammalian cells, endogenous H2S is primarily synthesized by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and th…

1,240 名社区成年人、10 年随访（120 例死亡）：全脑脑龄 HR 1.044/年，而三脑区模型 C-index 0.81 对 0.79；血浆蛋白组把机制指向补体激活与适应性免疫失调。

Young (3-4 months) and aged (12-14 months) mice were intracerebrally (i.c.) injected with amyloid-β (Aβ1 - 42) to develop an AD-li…

Once the iPSC cultures reached 60–80% confluence, the iPSC maintenance medium, StemMACS XF (Miltenyi Biotec, Auburn, CA, USA), was…

Histological and in vivo imaging studies have consistently demonstrated that retinal ganglion cells (RGCs) decline at an annual ra…

结论：Overall, SCeNS provides an effective tool that allows for the comparison and communication of diverse biological data.

The mice dedicated to immunohistochemical analysis were perfused intra- cardially with saline followed by 10% buffered forma- lin …

For peripheral line crossings, the Two-Way Repeated Measures ANOVA demonstrated a significant Time × Group interaction [F(4, 30) =…

The participants were predominantly male 72.1%. ‖ 结论：These findings support the potential of serum NfL as a non-invasive biomarker…

We found no significant main effect of sex on memory retention, F(1,58) = .13, p = .72, partial η2 = .002.；The overall model was n…

We delineated a nonlinear, diabetes-specific pathological trajectory characterized by early inflammatory activation, a mid-stage i…

The sample included 16 males (21.3%) and 59 females (78.7%), with mean age 72.32 years (SD = 6.03).；Age did not differ by sex (p =…

The 2024 Lancet Commission estimated that addressing 14 modifiable factors, including depression and social isolation, could preve…

In the aMCI group, NTA had the highest selection frequency (69.1%), followed by PA (52.0%) and PE (50.6%).；In older adults, PE was…

In this review, we examine how TDP-43 dysfunction disrupts lineage-specific glial homeostatic programs and promotes distinct patho…

In young rats, a statistically significant difference was observed among groups in terms of malondialdehyde (MDA) and sirtuin 2 (S…

结论：This study was designed to compare the predicted AD-related mechanisms of UDCA and TUDCA from the perspectives of target overla…

Nested model comparisons showed that incorporating these patterns significantly improved model fit across all 144 WM metrics—the m…

Seven-month-old male APP/PS1 mice were randomly divided into AD-vehicle and AD-hucMSC-exosome groups, with age-matched C57BL/6 mic…