同行评议人体研究
已在同行评议期刊发表的人体研究，包括随机对照试验、队列分析与临床试验中期数据。这是本站证据等级中可信度最高的一类。
如何解读这一层级
需注意：即使是 A 级人体研究，样本量与随访时长仍可能不足以支撑强结论。涉及企业发布的中期数据时，本站会在正文中另行标注。
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← 返回分级说明The current analyses included 7398 participants from the US Health and Retirement Study (HRS, mean age of 68.7 years, SD 11.0; 41% male) as the develo…
结论：Our findings demonstrate that the CKMS model effectively recapitulates a clinically relevant cardio–renal–metabolic state, characterized by profoun…
Of note, the improvement rate was between 15% and 30% in Patient 9 during the levodopa challenge test, whereas all other patients in this cohort achie…
Serum anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), luteinizing hormone and estradiol (E2) were measured; antral follicle count (A…
DHM increased mean lifespan to 21.78 ± 0.32, 22.45 ± 0.33, and 22.96 ± 0.34 days at 50, 100, and 200 μM, respectively, corresponding to extensions of …
[Convergent validity of WML volume] BAAD‐derived WML volume (from T1) agreed with the visual ratings from the independent FLAIR images: log WML/TIV co…
The mean age was 84.62 years (SD, 10.80), with 21.0% of participants aged 65 to 74 years, 31.2% aged 75 to 84 years, 36.0% aged 85 to 99 years, and 11…
We explored associations of diabetes and grip strength with skeletal outcomes using SHARE v8.0.0 (327 248 participants).；The primary analysis used a c…
In this cross-sectional study, buccal-lingual cross sections of extracted human premolars and molars obtained from donors aged 16 to 77 y were analyze…
The prediction showed an average structural similarity of 70.82% and a prediction accuracy of 69.26%, suggesting a moderate-to-good confidence level i…
It contained 24 geriatric libraries or pools spanning days 0, 1, 2, 3.5, 5 and 7 after notexin injury, together with eight young libraries at days 1 a…
We analyzed data from 42,987 participants aged ≥65 y who completed the Japan Gerontological Evaluation Study surveys in 2019 and 2022.；Oral frailty wa…
InPlp1Tgmice,theDAM1subpopulation,markedbypro-inflammatory cytokines and chemokines including Ccl4/Mip1b, was significantly expanded, comprising appro…
72 名认知未受损老年人单盲随机对照，训练组 30 分钟/天、每周 5 天、共 12 周；双侧毯部与右侧丘脑后辐射的 FA 下降显著小于对照，PAL 情景记忆改善（P=.04）。
Waist circumference measured in 2011 and 2015 was used to identify longitudinal patterns by K-means clustering, while C-reactive protein levels measur…
Consistent with age‐related declines in fitness, VO2peak was significantly greater in middle‐aged adults compared to older adults, p < 0.001, 95% conf…
No significant group differences were observed in age (p = 0.150), gender distribution (p = 0.818) and education duration (p = 0.337).；Cognitive asses…
We investigated the impact of the CDK4/6i palbociclib on mTORC1 signaling in TSC2-null human-derived cells, TSC2-deficient mouse embryonic fibroblasts…
Here, we identify a dynamic interplay between cellular vulnerability and circuit-level resilience that shapes cognitive outcomes in AD.；Conversely, a …
Of these almost 95% (n = 3095) completed the baseline assessment.；The cohort is predominantly of white ethnicity (98.9%), 59.9% female, and has a medi…
Mean inpatient GR duration was 33.1 days in the Better@Home group and 37.6 days in the control group (mean difference 4.5 days; 95% CI −1.7 to 10.7; p…
We analyzed 1488 participants from the National Alzheimer's Coordinating Center with autopsy-confirmed neuropathology and at least 2 caregiver-reporte…
To examine the association between incident AWVs and new dementia medication prescriptions.；Data analysis was performed from August 2025 to August 202…
FTLD-tau preferentially targets frontal and anterior temporal lobes, including the amygdala, contributing to severe neuropsychiatric symptoms.；This st…