同行评议人体研究
已在同行评议期刊发表的人体研究，包括随机对照试验、队列分析与临床试验中期数据。这是本站证据等级中可信度最高的一类。
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需注意：即使是 A 级人体研究，样本量与随访时长仍可能不足以支撑强结论。涉及企业发布的中期数据时，本站会在正文中另行标注。
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← 返回分级说明Spectra were searched with the open-search engine PIPI-C [20], which detects multiple co-occurring modifications on individual peptides [19], using th…
Direct comparison of the α-LA + AMB group against each monotherapy showed a significantly higher PAT than α-LA alone (p < 0.05), but no significant di…
At the highest ratios examined, fluorescence quenching reached 55% for curcumin, 72% for α-bromocurcumin, and 90% for α-chlorocurcumin.；Relative to th…
青年（20–30）、老年（55–65）与八旬/九旬老人（>85）三组中，吞噬与 NETosis 未随龄改变，但基线 ROS 升高、IL-8 升高，且 LTR/LINE 反转录转座子与干扰素应答基因同步上调。
Ophthalmologic examination was performed, including optical coherence tomography (OCT) and OCT-angiography (OCTA).；FAZ area, superficial capillary ple…
Inclusion criteria were (i) age > 3 years; (ii) PIMD/PLH diagnosis.；Data on health characteristics and health care consumption were included.；Adults w…
Analysis of demographic characteristics revealed no statistically significant difference in sex distribution between the age <65 years and ≥65 years g…
Age did not differ between the sexes, but female participants had higher VSTM (t = 3.91, p = 1 × 10-4) and ACE-R (t = 2.68, p = 0.01) scores and male …
The cutoff was set to the mean value + >2 SDs at 9-months, except from LVEF where the threshold was set to 40% to reflect the traditional clinical def…
In the primary cohort (N = 42), the older adults were less accurate overall, F(1, 40) = 9.54, p = 0.004, η2G = 0.156, and accuracy was lower in the an…
83.2 expected; fold enrichment 1.41; hypergeometric p = 8.9 × 10−5), with a weaker excess of AD-up/HT-down genes (108 vs. ‖ 结论：The findings are associ…
Cells were retained only when mitochondrial gene expression was below 5%, and filtering thresholds of 200–5000 for nFeature_RNA and 1000–20,000 for nC…
VitA 耗竭与 VitE 缺乏的患病率分别为 8.4% 与 20.7%；膳食生育酚/视黄醇摄入与缺乏状态无显著关联；VitE 状态组间肠道菌群组成无显著差异；但观察到 Veillonella 显著富集等差异；提示菌群–维生素轴可能存在"去区室化"（decompartmentalization）现象…
SRS 能有效将患者分层为不同预后组，并在内部划分的 TCGA-BRCA 子集中表现一致，高 SRS 患者生存显著更差。单细胞分析显示衰老活性主要富集于上皮与内皮细胞，而成纤维细胞是主要的信号发送群体，并介导与肿瘤细胞增强的胶原相关通讯。低 SRS 肿瘤表现出更高的免疫细胞浸润、更高的免疫检查点表达…
2,543 条记录中纳入 248 项研究（236 项原始研究、12 项系统综述/Meta：100 项 RCT、62 项队列、68 项横断面）。结论如题：以蛋白质为基础的策略与地中海式膳食展现出最一致的肌少症获益（摘要在此处被截断，具体效应量不可见）。
区域 BBBD 与较差的认知表现相对应，提示其可作为认知老化的生物学相关指标；为"认知下降异质性"提供了机制层面的解释路径。
TOS 在干预组下降更多（变化差值 −3.83 μmol/L；95% CI −7.03 至 −0.63；p=0.020；Hedges' g = −0.13）。端粒长度变化组间无显著差异（−0.170 log₂[T/S]；95% CI −0.554 至 0.214；p=0.382；g = −0.23）…
（摘要在方法描述后被截断，具体关联方向与强度不可见。）研究设计上同时纳入 7 种老化指标与 7 种炎症指数，是当前该问题上覆盖度较全的横断面分析之一。
未校正的横断面比较中，后续发生 SRE 者 6 种生物标志物升高（p<0.05）：VEGF-A、PD-1、IL-1α、SDF-1α、TNF-RII、TIM-3；队列以男性为主（85.6%，中位年龄 40 岁），中位 CD4⁺ 615 cells/mm³，中位随访 4.62 年；PD-1 与 MMP-…
老年人步态 SampEn 与扭矩 SampEn 呈中度正相关的证据（τ = 0.245, BF₁₀ = 3.985, 95% CI 0.042–0.435）；青年人则有中等证据支持二者不相关（τ = −0.079, BF₁₀ = 0.257）。即老年人运动控制网络出现"降维/自由度有效减少"，导致不…
较高的 PDI 与较低的衰弱风险相关（三个主队列 OR = 0.71–0.80），而较高的 uPDI 与较高风险相关（OR = 1.24–1.41）。hPDI 的负相关仅见于 ELSA，在 CLHLS 与 HRS 中为无效结果。在 CLHLS 中，个体间膳食差异的关联强于个体内变化。样条分析显示非线…
腰围越大，PAD 越高；CAPS-5 评分越高，PAD 反而越低；在低 CT 暴露人群中，MetS 状态与 PAD 升高相关；完全校正模型中 童年创伤 × MetS 的交互项为负且显著（b = −4.7, p = 0.025, 95% CI −8.7 至 −0.6）。Block I 中 PTSD 诊…
建立了"活动内容 × 环境场景"的联合刻画框架，并论证该耦合关系与老年人多维福祉相关，可为社区与邻里环境设计提供依据。
[Statistical analysis] All analyses used R 4.4.1 (R Foundation); two-sided P < 0.05 denoted statistical significance.；Survey-weighted Cox proportional…