同行评议人体研究
已在同行评议期刊发表的人体研究，包括随机对照试验、队列分析与临床试验中期数据。这是本站证据等级中可信度最高的一类。
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← 返回分级说明Each data point represents an individual mouse (n = 3 per group). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001; ns, not significant. ‖ 结论：These findings challe…
At week 1, final body weight did not differ significantly between D1 and C1 (p = 0.710), whereas final fasting blood glucose was higher in D1 than in …
Frailty prevalence was lower in the energy-sufficient group (6.1%) than in the energy-insufficient group (9.5%, p = 0.006).；Overall AMDR adherence did…
Parallel-process latent growth curve models examined level and change associations; additional analyses evaluated hearing-aid moderation, Mendelian ra…
Both attenuated after adjustment for age, sex and education, and only the Digit Span Backward association remained nominally significant (β = −0.11, p…
The mean age of the cohort was 69.54 years (SD = 8.66); 61.9% were female, and 56.6% were APOE ε4 carriers. ‖ 结论：The study protocol was reviewed and a…
结论：In conclusion, these findings identify miRNAs in L1CAM-enriched EVs as candidates for further investigation as minimally invasive markers in cognit…
Brain lipid deposition, plasma and brain TC, TG and NEFA levels, and expressions of BACE1, Aβ, p-Tau, ZO-1, occludin, AMPK/p-AMPK, SREBP1, ACC, ATGL, …
At 80% power and a two-sided α of 0.05, the median minimum detectable effect across expressed genes was an absolute log2 fold change of 0.465, corresp…
Specifically, each 1-SD increase in genetically predicted ESR1 expression was causally associated with a 1.26-SD reduction in PhenoAA (β =−1.26; 95% C…
The drug concentrations and conditions that gave more senescence induction with reduced cell lethality were chosen: 0.05 μM doxorubicin (DR or DoxoR),…
Age (F = 13.42, p < 0.001), sex (χ2 = 20.79, p < 0.001), and APOE ε4 carrier status (χ2 = 23.61, p < 0.001) all differed significantly across subtypes…
结论：In conclusion, HDL functional properties, specifically their capacity to remove excess cholesterol from neurons and to protect brain microvascular …
Frailty was assessed at consultation using the HCT-FS (fit, prefrail, frail).；OS was estimated by Kaplan-Meier, competing-risks methods by cumulative …
Using all available proxies, higher genetically predicted anti-H. pylori IgG seropositivity was associated with lower risk of Alzheimer’s disease (OR …
(n = 3 independent biological replicates) *p < 0.05; p < 0.01; *p < 0.001 (Rb1, ginsenoside Rb1; Young, EnSCs in the young female group; Aging, EnSCs …
Solid arrows indicate significant associations (P < 0.05); dashed arrows, non-significant. ‖ 结论：The present study demonstrated that regular ginseng in…
2,006 名 ≥65 岁急性老年医学科住院患者，6 个月死亡率 22%；CFS 每增加 1 分死亡风险升 50%，且衰弱越重、加权疾病负担的预后贡献被削弱（交互 p=0.011）。
Mean ± SD age was 77.1 ± 5.5 years (33% female), with a mean of 2.6 ± 2.0 comorbidities per participant in this highly educated cohort.；Twelve (66.7%)…
Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were reported.；Of these, 67.1% were classified as low HFRS, 31.5% as intermediate HFRS…
A total of 2,969 participants were included in the present study, with a mean age of 66.61 years; 1,495 (51%) were men and 1,474 (49%) were women.；In …
Understanding the mechanisms by which exercise activates autophagy and elicits metabolic benefits in the liver will provide important insights into th…
HPLC Method Validation] A reversed phase HPLC method was developed for trans-resveratrol (Inertsil ODS-3 column; acetonitrile/0.2% formic acid gradien…
The analytic sample included 442 cognitively healthy adults (mean age = 51.2 years, SD = 5.5; 50.7% women; mean education = 17.2 years, SD = 3.6).；[Re…