同行评议人体研究
已在同行评议期刊发表的人体研究，包括随机对照试验、队列分析与临床试验中期数据。这是本站证据等级中可信度最高的一类。
如何解读这一层级
需注意：即使是 A 级人体研究，样本量与随访时长仍可能不足以支撑强结论。涉及企业发布的中期数据时，本站会在正文中另行标注。
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← 返回分级说明Overall, the mean age was 56.48 years, 46.0% of participants were male, 95.9% were White, and 90.8% resided in England.；Among the 2,297 participants w…
UK Biobank 38,577 名基线无衰弱者，中位随访 9.37 年、1,024 例新发衰弱；DHA 每五分位间距 HR 0.82（95%CI 0.69–0.97），而非 DHA 的 n-3 与总 n-3 均不显著。
Primary analyses focused on relationships between plasma β-synuclein and synaptic density, and associations with related plasma biomarkers (tau phosph…
Each point represents an individual biomarker effect estimate (beta) and error bars represent the corresponding 95% confidence intervals (CIs).；Adjust…
NHANES 13,379 名中老年人，四项指标（AL、HD、PhenoAgeAccel、KDM Accel）一致显示中等活动量的效应最优；高活动量在主要模型中均无显著关联，且跨年龄组与 KDM Accel 呈一致正相关。
PVS were automatically quantified in basal ganglia, centrum semiovale, hippocampus, and midbrain on 3T MRI.；Counts were modelled using Poisson or nega…
Medications play a key role in the prevention and management of age-related CVDs, among which an important place is occupied by peptides, a special cl…
Regression lines and 95% CI (shaded areas) are presented for binarized groups defined by pPRS < 25th percentile (blue, “Low pPRS”) and > 75th percenti…
A systematic review of clinical studies demonstrates that a significant proportion of patients with partial edentia remain without prosthetic replacem…
APOE ε4 carrier frequency increased across the clinical groups, from 30.7% in CN to 50.0% in MCI and 71.3% in AD dementia (p < 0.001).；Cognitive and f…
UVA accounts for approximately 95% of the solar UV that reaches the Earth’s surface and penetrates deeply into the reticular dermis.；In addition, paeo…
Despite the relatively low 26.46% overall amino acid sequence identity between LMD-3 and human NCOA7 [25], the func- tional domains and critical motif…
In this cross-sectional study, 197 Japanese master athletes aged ≥ 35 years participated.；HRQoL was assessed using the Short Form-8, from which physic…
Although ovarian tumor protease deubiquitinase 1 (OTUD1) participates in various biological processes, its specific functions in PD and its regulation…
结论：The next generation of wound dressings and trials should therefore be state-aware, locally adaptive, and judged by durable restoration of tissue fu…
Formulations prepared with higher lecithin content (225 mg; N4–N6) were found to have significantly higher EE% (84.2–93.0%) than those with 150 mg of …
We used stringent criteria (|log2 fold change| > 1 and adjusted p < 0.05) to detect differentially expressed genes (DEGs).
More than half of the participants (53.42%, n = 86) had completed at least 12 years of education.；Notably, more than half of the participants (54.04%,…
How aging impacts neural tracking of speech and behavioral decrements in SIN perception remains unclear.；To address these questions, we measured neura…
(A) Relative abundance of the six most abundant genera (>5%) across the three clusters.；Letters above the boxes indicate significant pairwise differen…
Significant differences between treatment groups were observed for BMI (p < 0.001), fasting plasma glucose (p < 0.001), IRI (p < 0.001), HOMA-IR (p < …
Organ age gap (OAG) was defined as predicted age minus chronological age.；Predicted and chronological age were strongly correlated across organs (aver…
(C) Volcano plot of DEGs between PAH and Controls (|log2FC| > 0.5, adjusted P < 0.05). ‖ 结论：Our findings suggest that a senescence-associated transcri…
Here we show that NgBR is highly expressed in microglia, where its deficiency drives progressive PD-like motor deficits and dopaminergic neurodegenera…