同行评议人体研究

已在同行评议期刊发表的人体研究,包括随机对照试验、队列分析与临床试验中期数据。这是本站证据等级中可信度最高的一类。

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需注意:即使是 A 级人体研究,样本量与随访时长仍可能不足以支撑强结论。涉及企业发布的中期数据时,本站会在正文中另行标注。

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研究进展 A 2026-10-29 生命历程

This study aimed to examine age- and sex-related differences in NWES-derived swallowing-related time metrics and their relationship with masticatory f…

流行病学 A 2026-10-29 器官衰老

Matching achieved close balance on all variables entered into the assignment: the standardised mean difference was 0.15 for age, −0.02 for height, and…

研究进展 A 2026-10-29 神经退行

In the aMCI group, NTA had the highest selection frequency (69.1%), followed by PA (52.0%) and PE (50.6%).;In older adults, PE was most frequently sel…

研究进展 A 2026-10-29 生命历程

SOY reduced final BW in the βKO mice by ~17%, which was not evident in the WT (0%) or αKO (6%) mice.;This associated with a trend toward lowered fat m…

流行病学 A 2026-10-29 生命历程

The study duration averaged 70 months (SD 5.38) with a sample mean age of 62 years (9.83) and 60.64% women.;There was evidence of effect modification …

研究进展 A 2026-10-29 神经退行

The sample included 16 males (21.3%) and 59 females (78.7%), with mean age 72.32 years (SD = 6.03).;Age did not differ by sex (p = 0.614), nor did oth…

流行病学 A 2026-10-29 器官衰老

The majority of participants were married (92.33%), resided in rural areas (64.27%), did not consume alcohol (64.31%), and were nonsmokers (68.35%).;E…

研究进展 A 2026-10-29 生命历程

To formally assess bioequivalence, 90% confidence intervals (CIs) were calculated for the geometric mean ratios (Test/Reference) of the log-transforme…

研究进展 A 2026-10-29 生命历程

Transfected cells were treated with cambinol (100 µM), vehicle control (VC), and VC containing 1% DMSO to match the DMSO concentration present in 100 …

研究进展 A 2026-10-29 器官衰老

Therefore, the aim of this study was to investigate the effect of a hyaluronic acid-based hydrogel with a chelated form of zinc and silicon on the exp…

研究进展 A 2026-10-29 神经退行

We found no significant main effect of sex on memory retention, F(1,58) = .13, p = .72, partial η2 = .002.;The overall model was not significant, F(4,…

流行病学 A 2026-10-29 代谢与营养

Coefficients were exponentiated and reported as percentage differences with 95% CIs.;Their 95% percentile CIs were obtained by case bootstrapping with…

研究进展 A 2026-10-29 代谢与营养

Among boys, higher NA concentrations at baseline were associated with lower internalizing (β = −3.733, 95% CI: −6.686 to −0.779), externalizing (β = −…

流行病学 A 2026-10-29 神经退行

The participants were predominantly male 72.1%. ‖ 结论:These findings support the potential of serum NfL as a non-invasive biomarker for early detection…

研究进展 A 2026-10-29 细胞衰老

After Benjamini–Hochberg correction across the six two-sided tests, all six had BH-adjusted q values below 0.10, although only one met the prespecifie…

研究进展 A 2026-10-29 生命历程

We analysed clinical data from 69 patients aged 65–83 years (median age 74 years), representing 2.9% (69/2378) of all new STIs diagnoses recorded betw…

研究进展 A 2026-10-29 神经退行

The mice dedicated to immunohistochemical analysis were perfused intra- cardially with saline followed by 10% buffered forma- lin and immersion fixed …

研究进展 A 2026-10-29 器官衰老

It is an important risk factor for cardiovascular diseases (CVD) and accounts for 20% of deaths worldwide [3].;Most patients develop primary hypertens…

研究进展 A 2026-10-29 器官衰老

A CGA was performed, supplemented with age-related resilience scales.;The analysis of the interrelationships between the levels of age-related resilie…

流行病学 A 2026-10-29 神经退行

1,240 名社区成年人、10 年随访(120 例死亡):全脑脑龄 HR 1.044/年,而三脑区模型 C-index 0.81 对 0.79;血浆蛋白组把机制指向补体激活与适应性免疫失调。

研究进展 A 2026-10-29 器官衰老

Here we test the mechanistic role of ROR2 in RVF pathogenesis.;ROR2 was overexpressed or knocked down in neonatal rat ventricular myocytes and then ch…

流行病学 A 2026-10-29 神经退行

80.8 ± 7.4 years, p < 0.001) and had a higher burden of age-related comorbidities.;11.9%), chronic obstructive pulmonary disease (19.0% vs.;9.2%) were…

研究进展 A 2026-10-29 生命历程

In South America, Brazil was consistently classified in low–low clusters for AHEI, with a median local Moran’s I of 0.92 (95% UI 0.56–1.17).;In East A…

研究进展 A 2026-10-29 神经退行

The mean planning latency in patients with fibromyalgia (11,985 (915) ms) was not significantly different from that in the control group (10,424 (671)…