器官特异性衰老

We explored associations of diabetes and grip strength with skeletal outcomes using SHARE v8.0.0 (327 248 participants).；The prima…

During weeks 1–12, the body weight of the HFD groups was significantly higher than that of the DC group (p < 0.05 or p < 0.01), in…

D-半乳糖诱导衰老大鼠接受健康供体粪菌移植后，水迷宫成绩改善，心脏、海马与结肠的组织损伤同步减轻；预先用抗生素清场反而削弱了效果。

Mean ± SD age was 77.1 ± 5.5 years (33% female), with a mean of 2.6 ± 2.0 comorbidities per participant in this highly educated co…

Statistical data are presented as the mean ± SD (P < 0.01, P < 0.0001).；Statistical data are presented as the mean ± SD (*P < 0.05…

Frailty was assessed at consultation using the HCT-FS (fit, prefrail, frail).；OS was estimated by Kaplan-Meier, competing-risks me…

（原文未设独立引言节）

At 80% power and a two-sided α of 0.05, the median minimum detectable effect across expressed genes was an absolute log2 fold chan…

心脏富集的小非编码 RNA piR-4913 在衰老心脏 I/R 后显著上调，缺血后处理可抑制它；沉默 piR-4913 缩小梗死面积、提升 ATP 并降低氧化应激，机制落在 Drp1 Thr604 的 O-GlcNAc 修饰。

A single prospective cohort, the Osteoporotic Fractures in Men Study [22], contributed 53% of all participants, and the two larges…

Frailty prevalence was lower in the energy-sufficient group (6.1%) than in the energy-insufficient group (9.5%, p = 0.006).；Overal…

How aging impacts neural tracking of speech and behavioral decrements in SIN perception remains unclear.；To address these question…

Pairwise Meta-Analysis] For muscle mass, pooled results from nine studies showed that, compared to control, nutritional interventi…

Studies developing or validating oral frailty assessment instruments in older adults were included.；Clinical measures were summari…

In this cross-sectional study, 197 Japanese master athletes aged ≥ 35 years participated.；HRQoL was assessed using the Short Form-…

Significant heterogeneity was observed across the studies (P < .00001, I2 = 97%).；Similarly, significant heterogeneity was noted a…

However, advances in the understanding of OA pathogenesis have led to the emergence of therapeutic strategies targeting metabolic …

Medications play a key role in the prevention and management of age-related CVDs, among which an important place is occupied by pe…

Approximately 35% of the encapsulated protein was released within the first hour, followed by cumulative release values of approxi…

Here we test the mechanistic role of ROR2 in RVF pathogenesis.；ROR2 was overexpressed or knocked down in neonatal rat ventricular …

A CGA was performed, supplemented with age-related resilience scales.；The analysis of the interrelationships between the levels of…

It is an important risk factor for cardiovascular diseases (CVD) and accounts for 20% of deaths worldwide [3].；Most patients devel…

We observed an increase in body weight in female 3xTg-AD mice at 6 months (24.1%) and 12 months (28.3%) compared to B6129 mice.；Th…

Therefore, the aim of this study was to investigate the effect of a hyaluronic acid-based hydrogel with a chelated form of zinc an…