器官特异性衰老
心脏、肝脏、肌肉、骨骼、卵巢等器官的衰老机制与干预。不同器官的衰老速率差异显著。
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Structural equation modeling showed that greater xerostomia symptom severity was not significantly associated with nutritional vul…
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641,748 名 2018 年 1 月 1 日时 ≥65 岁成员（开发集 n=321,019、验证集 n=320,729）的 36 项缺陷电子衰弱指数 CeFI，一年全因死亡率由健康者（CeFI≤0.12）的 0.9% 升至重度衰弱（Ce
出生后内皮细胞表达 TIE2L914F 的小鼠出现与患者组织学相似的扩张静脉病灶，mCherry 示踪显示病灶源于静脉血管系统、突变内皮经"早期增殖爆发+随后细胞增大"的双相机制克隆扩增，雷帕霉素部分减少病灶生长并延长生存。摘要未给定量。
在两个独立人类衰老队列（发现 n=22、验证 n=33）中用年龄校正的计时起立-行走（TUG）残差量化躯体衰弱，配血浆 OLINK 蛋白质组、高维光谱流式、PBMC 单细胞转录组＋配对 TCR 谱，再在一个独立人骨骼肌队列（n=340）做
对年轻与年老脂肪做 snRNA-seq，用两套独立分析策略（其一基于 SenMayo，其二基于 SEAC 指南 + 皮尔逊相关）交叉验证，两套方法都把衰老核团定位在内皮细胞簇；进一步亚聚类与细胞间通讯分析识别出过表达巨噬细胞迁移抑制因子（M
把单细胞转录组分析 ＋ 人用证据挖掘 ＋ UPLC/Q-TOF-MS 化学表征 ＋ 预训练蛋白分子表示模型整合成一个筛选框架：从 GEO 的卵巢衰老单细胞数据识别出类固醇合成受损、颗粒细胞-免疫细胞 MDK–NCL 通讯增强、细胞外基质重塑
在 2024 年日本 9 家学术医院的非增强躯干 CT（15–100 岁）中，用 TotalSegmentator v2.10.0 掩膜测 25 个椎体 + 24 根肋骨的平均 CT 值：从 239,766 次检查／135,425 名患者筛
FDA 放行 United Therapeutics 的 IND，允许开展 SUMMIT 试验：手持软雾吸入器给药的吸入型前列环素类似物治疗 COPD 相关肺动脉高压（PH-COPD），Phase 2，约 40 例，每日 4 次、每次 1 吸。
The cutoff was set to the mean value + >2 SDs at 9-months, except from LVEF where the threshold was set to 40% to reflect the trad…
Inclusion criteria were (i) age > 3 years; (ii) PIMD/PLH diagnosis.；Data on health characteristics and health care consumption wer…
Ophthalmologic examination was performed, including optical coherence tomography (OCT) and OCT-angiography (OCTA).；FAZ area, super…
在 D-半乳糖诱导的毛细胞衰老与 C57BL/6J 小鼠增龄模型中，褐藻寡糖降低 SA-β-gal 与 P16/P21、抑制 NF-κB/NLRP3，长期给药降低 ABR 阈值并减少毛细胞与螺旋神经节变性。
Direct comparison of the α-LA + AMB group against each monotherapy showed a significantly higher PAT than α-LA alone (p < 0.05), b…
We investigated whether altered AQP4 expression contributes to age-related defects in skeletal muscle regeneration and whether AQP…
Statistical analysis is by unpaired two-tailed t test. ∗∗∗∗p < 0.0001.；B. fragilis was grown anaerobically in BHI-S (BHI with 0.5%…
Most studies were retrospective (91.2%, n = 31) and 7 (20.6%) were multicenter.；Twenty-one studies (61.8%) originated from Eastern…
Waist circumference measured in 2011 and 2015 was used to identify longitudinal patterns by K-means clustering, while C-reactive p…
We analyzed data from 42,987 participants aged ≥65 y who completed the Japan Gerontological Evaluation Study surveys in 2019 and 2…
It contained 24 geriatric libraries or pools spanning days 0, 1, 2, 3.5, 5 and 7 after notexin injury, together with eight young l…
The expected amount of furfural formed by C5 hydroxylation relative to 5-methylene-2-furanone (C1 hydroxylation) is 15%.；The only …
In this cross-sectional study, buccal-lingual cross sections of extracted human premolars and molars obtained from donors aged 16 …